How does real-world evidence complement RCTs, and why is it important for small patient populations?
Real-world evidence (RWE) and randomized controlled trial (RCT) data each have both advantages and disadvantages, and they can be complementary. In general, outcomes of real-world studies are given lower credibility compared with RCT research, which is characterized as having the highest reliability. However, real-world studies can be particularly advantageous in specific patient populations, for instance in chronic graft-versus-host disease (cGvHD), which may have a lack of RCT data.
The GvHD Hub spoke to Steven Pavletic, National Cancer Institute, Bethesda, US, about his perspectives on how…
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