1045-Multilayered Regulatory Control of T Cell Exhaustion
This review explores how T cell exhaustion is governed by a complex synergy of epigenetic, epitranscriptomic, and metabolic networks. Chronic exposure to tumors triggers a dysfunctional state in T cells, characterized by a progressive loss of effector function and stabilized by fixed chromatin landscapes. Key metabolites like alpha-ketoglutarate and acetyl-CoA act as essential cofactors that link cellular energy states directly to gene regulation. Scientists are investigating various therapeutic interventions, such as CRISPR-based engineering and transient pharmacological inhibition, to…
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