1455-Multi-omics Profiling of Cervical Cancer Evolution

Paper Talk · Aug 18, 2026 · 23m

This research paper utilizes single-cell RNA sequencing and spatial transcriptomics to map the progression of cervical cancer from healthy tissue to malignant tumors within the same patients. The study identifies a distinct spatiotemporal architecture characterized by a shift toward an immunosuppressive microenvironment, marked by changes in fibroblast, endothelial, and B-cell subpopulations. Researchers highlight a specific gene signature—CLDN1, ISG15, and PTGDS—as vital biomarkers for early diagnosis and therapeutic intervention. Mechanistically, ISG15 is shown to stabilize FGF1, thereby…