874-Neuroanatomical and Behavioral Mapping of Alzheimer

Paper Talk · Apr 29, 2026 · 24m

This research utilizes high-resolution magnetic resonance microscopy to map the extensive structural and behavioral impacts of Alzheimer’s disease mutations in diverse mouse models. By examining over 200 brain regions, researchers discovered a distinct rostrocaudal gradient where the front of the brain swells while the brainstem and white matter tracts shrink, leaving the total brain volume unchanged. The study highlights how genetic background and sex significantly influence the severity of these anatomical changes and their associated memory deficits. Female mice exhibited higher structural…