How to build an AI-native team & company: The six-principle playbook from Y-Combinator

In The Loop · May 7, 2026 · 26m · transcript

Y Combinator have just published a playbook for building a company that runs on AI rather than just using it.

Six principles, written by a general partner who works with hundreds of the very best leading AI-native startups every year.

The reason its gone viral so fast is that it named something a lot of people had been watching happen without quite having the language for.

In this episode of In The Loop, I'm walking through Diana Hu's framework for building a truly AI-native company. I cover all principles and how you can do the same in your team or company — from running AI as your operating…