Latest / Skin Anarchy / Healthy Skin Starts With Healthy Fats ft. fatty15
Transcript
- 0:06SPEAKER_01: Okay guys, thank you guys to be another episode of Executria Anarchy.
- 0:10SPEAKER_01: This is your host, Ecta, and I am so delighted to introduce you guys to our wonderful guests today.
- 0:16SPEAKER_01: They are the founders of this beautiful supplement brand that I have been thoroughly enjoying for the last, I think, about it's almost been about 60 days, right?
- 0:25SPEAKER_01: Um, I I think it's been about two months now, but um a little short of that, and I've really noticed a difference even in my own um self in terms of my energy.
- 0:35SPEAKER_01: Um, I'm somebody who um, you know, I have a lot of other things going on as well.
- 0:40SPEAKER_01: Like, you know, I've suffered from depression before.
- 0:42SPEAKER_01: I've gone through a lot of things.
- 0:43SPEAKER_01: And when I, you know, test a supplement brand out, I'm always looking for signs of improvement in a lot of different areas of my life.
- 0:50SPEAKER_01: And I've definitely noticed that there have been some improvements for me.
- 0:54SPEAKER_01: So I'm really excited.
- 0:55SPEAKER_01: And without further ado, I want to introduce you guys to the co-founders of Fatty15, Steph and Eric.
- 1:02SPEAKER_01: Uh, welcome to the show, Dr.
- 1:04SPEAKER_01: Steph and Eric.
- 1:05SPEAKER_01: I'm so excited to host both of you.
- 1:07SPEAKER_01: Great.
- 1:07SPEAKER_01: Thanks, Ecta.
- 1:08SPEAKER_01: Wonderful to be here.
- 1:09SPEAKER_02: Agreed.
- 1:10SPEAKER_02: Thank you very much for having us.
- 1:12SPEAKER_01: Oh, it's lovely to host both of you.
- 1:14SPEAKER_01: And um, like I said, you know, I am a huge fan of the brand myself because I've actually gotten a chance to try it.
- 1:20SPEAKER_01: And I can't wait to dive into that.
- 1:22SPEAKER_01: But I know you're both um, you know, you have this medical background and you have this um scientific background.
- 1:27SPEAKER_01: And I really want to dive into that and learn about um where you started FATI 15 from, like where the idea came from, and really about you and both of you and um your backgrounds, if you could get us started.
- 1:40unknown: Great.
- 1:41SPEAKER_02: Oh, I'll start.
- 1:42SPEAKER_02: Uh, my name is Eric.
- 1:43SPEAKER_02: I'm a Navy and Marine Corps physician, uh, backgrounds in surgery and aerospace medicine, and spent 26 years doing that, and then became very entrepreneurial afterwards.
- 1:53SPEAKER_02: So um uh I started a few companies in the the medical space, uh, one being a medical device company, one being a digital health company that I worked with.
- 2:02SPEAKER_02: Um, and I am big on bringing new and innovative technologies to the world that improve health and wellness.
- 2:09SPEAKER_02: Very nice to be here.
- 2:10SPEAKER_02: Thank you.
- 2:12SPEAKER_01: That's very cool.
- 2:13SPEAKER_01: That's really, really cool.
- 2:15SPEAKER_01: What about you, Steph?
- 2:16SPEAKER_00: Yeah, hi.
- 2:17SPEAKER_00: Uh Steph.
- 2:18SPEAKER_00: So I am a veterinary epidemiologist.
- 2:20SPEAKER_00: So not your typical um background for uh for this topic.
- 2:25SPEAKER_00: Uh it was a delight and surprise uh for our lives for this discovery to be made.
- 2:31SPEAKER_00: Um, I was, you know, working for the World Health Organization, ECTA, and um helping with infectious disease surveillance systems, like setting them up all over the world.
- 2:40SPEAKER_00: And then um I was invited by the Navy to help start and lead clinical research programs to continually improve the health and welfare of Navy dolphins, which again was a surprise, wasn't it?
- 2:56SPEAKER_00: And so it was pretty awesome.
- 2:58SPEAKER_00: I thought, oh gosh, we'll do it for a couple of years.
- 3:00SPEAKER_00: It's gonna be super fun.
- 3:01SPEAKER_00: Ended up doing it for 20.
- 3:04SPEAKER_00: Um, and uh in part because you know the Navy's taken extraordinarily good care of like a population of about like a hundred bottlenose dolphins that live in the open ocean.
- 3:16SPEAKER_00: They take such good care of them um over the past 60 years that Navy dolphins live, you know, on average 50% longer than dolphins in the wild.
- 3:28SPEAKER_00: So as I started living longer as their epidemiologist, my job um was then to help understand why some dolphins were aging healthier than others.
- 3:40SPEAKER_00: And what was fascinating was that, you know, dolphins age like us, like they get high cholesterol and they get inflammation and arthritis and fatty liver disease and the full suite of Alzheimer's.
- 3:52SPEAKER_00: So yeah, it was fascinating.
- 3:54SPEAKER_00: So um uh we were able to leverage a technology, advanced technology called metabolomics.
- 4:01SPEAKER_00: And it looks basically looking at small molecules, um, uh, this in this case in the serum that they had archived from the dolphins as part of their routine healthcare.
- 4:11SPEAKER_00: And we found we looked at thousands of small molecules present in dolphins' blood, but also in ours, uh that predicted the healthiest aging dolphins.
- 4:20SPEAKER_00: And among those, we uh discovered about a hundred uh molecules that predicted healthier agers.
- 4:27SPEAKER_00: And uh on the top, on among the top, there was C15 uh pentadeconoic acid.
- 4:33SPEAKER_00: Um so it started, kicked off this whole discovery of C15.
- 4:38SPEAKER_01: Wow, that is so cool.
- 4:40SPEAKER_01: That's really neat.
- 4:42SPEAKER_01: I mean, I've heard a lot about dolphins, you know, just throughout the years, right?
- 4:45SPEAKER_01: You learn about it through a discovery channel or, you know, somebody who was a really big enthusiast, um, you know, when it comes to just animals and especially veterinarians, you know, along the way, um, I've always met, you know, friends and and colleagues that have been in veterinary medicine.
- 5:01SPEAKER_01: And, you know, you always learn that dolphins are such fascinating animals.
- 5:05SPEAKER_01: And so that is really cool.
- 5:07SPEAKER_01: I mean, to be able to analyze, you know, the things that are within them that are helping them stay healthy and robust.
- 5:14SPEAKER_01: That's amazing.
- 5:15SPEAKER_00: Yeah, it was a huge gift, right?
- 5:18SPEAKER_00: And an honor for us.
- 5:19SPEAKER_02: They're a very good model to study, a very good patient population because they exercise, they only eat fish, they don't have many of the same vices that we have, and they're not on chronic medications or doing, you know, things that uh we like drinking coffee and other things.
- 5:34SPEAKER_02: And so a very good population to understand the pathophysiology of chronic diseases of aging.
- 5:41SPEAKER_01: Yeah, absolutely.
- 5:43SPEAKER_01: You know, I think that that's so fascinating because I think uh I heard somewhere that dolphins also utilize uh more areas of their brain than we do when they did neural imaging on them, right?
- 5:54SPEAKER_01: Is that correct, Steph?
- 5:55SPEAKER_01: I don't know if they do.
- 5:57SPEAKER_00: They, I mean, it's it's pretty it's pretty amazing.
- 6:00SPEAKER_00: They um, you know, they have this capability that um we don't, uh, and which is echolocation.
- 6:07SPEAKER_00: And so they're able to, you know, send out clicks in the ocean and then listen to the clicks come back to them as it bounces off of objects, and through that, they can actually tell they know what the object is, you know, in the water.
- 6:23SPEAKER_00: So it's so they are they, in addition to all the intelligence and socialization and all these wonderful aspects of having large brains like we do, they've added in the superpower of of echolocation, which is really neat.
- 6:36SPEAKER_01: That is really neat.
- 6:37SPEAKER_01: Yeah, absolutely.
- 6:39SPEAKER_01: So, you know, I I'm just so curious, you know, because I I'm sure this was really, really difficult to um, you know, first of all, come up with and also like nail down, right?
- 6:49SPEAKER_01: I mean, I can't imagine the process.
- 6:50SPEAKER_01: How long did it take you guys to really kind of um figure this out and find C15 and you know, really um uh, you know, just kind of bring bring it out as like a concept that you wanted to, you know, really bottle up for people to to experience as like a supplement?
- 7:07SPEAKER_00: Yeah, it's been a it's been at least a decade journey, uh maybe more.
- 7:13SPEAKER_00: So first it was discovering dolphins age a lot like us and spent years and years documenting, studying, and publishing all of that, and everything we published in the peer-reviewed scientific literature.
- 7:25SPEAKER_00: And then from there, like we said, doing these metabolomic studies, discovering these molecules.
- 7:30SPEAKER_00: And so once we saw C15 as a promising molecule, then we moved from the dolphins um to the lab.
- 7:38SPEAKER_00: Um, and that's where we went to experts in fatty acids and we said, hmm, well, you know, healthier aging dolphins have higher C15 levels than less healthy aging dolphins.
- 7:49SPEAKER_00: Could C15 be a healthy aging molecule?
- 7:53SPEAKER_00: And we went to experts, and actually, you know, to be honest, they're like, well, chances are as a dolphin veterinarian and Navy physician, you know, you didn't make this discovery.
- 8:02SPEAKER_00: Like probably not, but here are the studies you would need to do to figure out how C if C15 is beneficial.
- 8:09SPEAKER_00: And so we did eight studies over three years.
- 8:13SPEAKER_00: We partnered with the Navy, um, because it was now, you know, discovery was made while we were at the Navy.
- 8:18SPEAKER_00: Um, so then we partnered with the Navy, spun out um seraphino therapeutics to then advance um the science on C15.
- 8:27SPEAKER_00: So we went to the lab, uh, eight studies over three years to show that C15 is not only an active and beneficial saturated fatty acid, but that it meets these rare criteria of being the first essential fatty acid to be discovered since omega-3 and omega-6.
- 8:46SPEAKER_00: Um, so, and that paper was led by Dr.
- 8:50SPEAKER_00: Ed Dennis, who is a leader in lipids, editor of Journal for Lipid Research, uh, for 15 years.
- 8:57SPEAKER_00: So we were real excited about that.
- 8:59SPEAKER_00: This is an essential nutrient, not just for dolphins, but for humans.
- 9:06SPEAKER_01: Well, first of all, to the naysayers, boo, okay, that said that, that you couldn't have discovered this.
- 9:12SPEAKER_01: Um, this is so freaking amazing, first of all.
- 9:15SPEAKER_01: I mean, that's that's what an accomplishment.
- 9:18SPEAKER_01: I mean, this is really, really huge because you're right.
- 9:21SPEAKER_01: I mean, we don't know much about essential fatty acids, you know, even like the omegas, you know, when you look at just the general consumer and the general public, I mean, uh, you know, I'm sure Eric, you know all about this too.
- 9:32SPEAKER_01: Like, I mean, how many of your patients can you say know about, you know, just omegas?
- 9:36SPEAKER_01: Like, you know, you talk to them and they're like, I don't know, something about fish oil.
- 9:40SPEAKER_01: That's what I always get, at least.
- 9:41SPEAKER_01: You know, every patient I've ever had is like, I don't know.
- 9:44SPEAKER_01: I I know I have to take fish oil, I just don't I don't get it.
- 9:47SPEAKER_01: So I know that it's I mean, this is absolutely huge.
- 9:51SPEAKER_01: So yeah, I mean, wow, I'm I'm just floored that you guys found this.
- 9:56SPEAKER_01: This is really cool.
- 9:57SPEAKER_02: Yeah, yeah.
- 9:58SPEAKER_02: I mean, there are a lot of different variations of essential fatty acids of the omega-3s, and you're you're correct in that a lot of my patients.
- 10:07SPEAKER_02: Uh, we used to have actually omega-3s on the formulary, but they take took them off.
- 10:11SPEAKER_02: So now if people want omega-3s, they have to go purchase them themselves.
- 10:14SPEAKER_02: But there is so much variation in quality.
- 10:17SPEAKER_02: There is fish oil that's already oxidized all the way to pure prescription EPA.
- 10:23SPEAKER_02: And so there's a lot of confusion on I know I need essential fatty acids, which do I get?
- 10:29SPEAKER_02: And how do I make sure it's a high quality product?
- 10:31SPEAKER_02: So I get a lot of that as well.
- 10:33SPEAKER_01: Yeah, yeah.
- 10:34SPEAKER_01: No, absolutely.
- 10:35SPEAKER_01: And you know, that's the thing is that quality aspect of things.
- 10:38SPEAKER_01: I feel like there were some studies done, you know, just for our audience's sake, I just want to mention, I think there were some studies done that I came across about a couple of years ago about how fatty acids were not actually improving, you know, things that they were claiming to improve, such as, for example, bad cholesterol levels, right?
- 10:55SPEAKER_01: Like there were a lot of studies out there.
- 10:58SPEAKER_01: Um, it was almost, I feel like it was kind of like fear-mongering because I feel like these days you can publish a study about a lot of things that might not be fully true.
- 11:06SPEAKER_01: You know, you can mold the statistics a little bit.
- 11:09SPEAKER_01: So, you know, um, I know that there I had some people ask me questions about that, but for the listeners out there, I mean, fatty essential fatty acids are very important for your health, you know, it's really, really important.
- 11:19SPEAKER_01: And I think um, you know, like Eric mentioned and uh Stephanie as well, I mean, it's it's something like dolphins are eating only fish, which is what we tell you to eat, right?
- 11:29SPEAKER_01: As like just patients or just people in general, we should be eating things more like fish, nuts, you know, healthy berries, those kind of things, like uh instead of what we'd eat, like red meat, you know, whatnot.
- 11:41SPEAKER_01: So I think it's just a really, really important area of study and just medicine in general.
- 11:45SPEAKER_01: So for you guys to find this, I mean, and put it into a supplement source is so huge because we already have this, like, you know, in medicine, I know like I've told so many patients to go take some fish oil, and they're like, no, absolutely not.
- 11:59SPEAKER_01: I won't do it.
- 12:00SPEAKER_01: Or if they say they're gonna do it, they don't stick to it.
- 12:02SPEAKER_01: So this idea of not really sticking to the routine, you know, um, adherence, it's a huge problem, you know.
- 12:08SPEAKER_01: So this is a really, really neat discovery, um, honestly.
- 12:12SPEAKER_01: Um, with that said, I want to ask some questions, um, if you don't mind, because I'm really curious about, you know, when it came to the testing, like what were some of the things that you guys really found um that were very interesting to you, you know, things that could be really beneficial for us as humans.
- 12:29SPEAKER_00: Yeah, so uh it's I think what's fascinating about C15 is it's you know, it's a very um, we'll call it a promiscuous molecule that is good at doing a lot of different things, which is what you'd expect of an essential fatty acid, right?
- 12:51SPEAKER_00: If there are so few, if this is only the third discovered, then nature's really good at taking a molecule, especially these essential ones, and making them good at doing a lot of things.
- 13:02SPEAKER_00: So when we moved it to the lab and we've done these studies, and now, you know, I think there's like there's over 50 studies from prestigious teams throughout the world with whom, you know, we have no associations with Harvard and Hopkins and Cambridge, and they're all doing their own work and showing the same benefits, which has been for as a scientist, you know, so exciting and fulfilling.
- 13:27SPEAKER_00: Um, but what we what we showed in the in the lab and what we've shown in the studies and now others is that C15 is really important for maintaining our cellular health.
- 13:37SPEAKER_00: So we're made of cells, our skin is cells, right?
- 13:40SPEAKER_00: Our heart cells, our livers are cells.
- 13:42SPEAKER_00: So it has three main jobs.
- 13:45SPEAKER_00: Um, C15's first job is it is a stable, odd-chain saturated fatty acid, which means it's highly resistant to oxidative stress and to oxidation.
- 13:57SPEAKER_00: And so it has a primary role of this fatty acid of C15 going into our cell membranes, which is, you know, the whole whole membranes are made out of lipids, of going into our cell membranes and physically storing them up against oxidation and age-related breakdown.
- 14:15SPEAKER_00: So it literally is like an armor for our cells.
- 14:18SPEAKER_00: There's a fascinating um theory called the cell membrane peacemaker theory of aging by Holbert.
- 14:25SPEAKER_00: Um, and he showed that the more saturation of fats a mammal has in its cell membrane, the longer it lives.
- 14:34SPEAKER_00: So it's really important to life.
- 14:37SPEAKER_00: Uh so and it ends up C15's, you know, like probably one of the most essential molecules for that.
- 14:43SPEAKER_00: So that's the first.
- 14:43SPEAKER_00: The second is it repairs mitochondria.
- 14:46SPEAKER_00: So we're able to show um that it uh basically repair has a rescue function in which it can repair our mitochondrial function, obviously maintaining cellular energy, keeping our cells functioning, those powerhouses of our cells, right, um, going is critical.
- 15:02SPEAKER_00: And the third is it helps improve cellular signaling.
- 15:06SPEAKER_00: So it helps it activates PPAR alpha delta, amp K, and then it inhibits pro-inflammatory pathways like JACstat and HEC as inhibitors.
- 15:17SPEAKER_00: So it helps balance through the signaling, strengthen our cells through its physical properties and keeping our cellular energy going.
- 15:25SPEAKER_00: So pretty impressive for a really small 15 carbon.
- 15:30SPEAKER_02: Before we put out the uh the supplement, right, we had actually moved this forward as a pharmaceutical for NAFOLD and NASH and different different diseases.
- 15:38SPEAKER_02: And we had one of our advisors who's a leader in the world, he basically said, Hey, this is a natural molecule.
- 15:43SPEAKER_02: You have the moral obligation to bring this out to the world.
- 15:46SPEAKER_02: And so we created this ingredient, and then you know, we thought that people would just read nature and read public library of science, and no one does that.
- 15:56SPEAKER_02: So we said, okay, how do we get the world to know that about C15 deficiencies, about this new essential fatty acid, and get it back into people's the global food food supply?
- 16:07SPEAKER_02: And so we started, we we started that with Fatty 15 the supplement.
- 16:11SPEAKER_02: And we named it Fatty 15 because it's a fatty acid 15 because there's 15 carbons in the backbone.
- 16:16SPEAKER_02: So we came out with that in 2021.
- 16:19SPEAKER_02: So it's been really recent and it sold out in six weeks.
- 16:22SPEAKER_02: We were ingredient producer of the year uh at the first year, fast company world changing idea, front page of the New York Times uh science section.
- 16:30SPEAKER_02: It's really taken off, which is great.
- 16:32SPEAKER_02: And now we've had over 60,000 people take this.
- 16:35SPEAKER_02: And getting to the point of the discussion here was we knew that people would have long-term benefits, benefits to their you know, glucose levels, their lipid panels, their CBC, their liver enzymes, you know, for the chronic disease of aging that we talked about.
- 16:51SPEAKER_02: Um, what we didn't know is people would have these near-term benefits.
- 16:54SPEAKER_02: So every morning I get to wake up to more testimonials that people leave on our website, uh, which is really exciting.
- 17:00SPEAKER_02: So, with regards to hair, I just looked those up just now.
- 17:03SPEAKER_02: These just popped up, and anyone can look at our website and look at these reviews.
- 17:07SPEAKER_02: Uh, my skin is starting to get its glow back.
- 17:10SPEAKER_02: I'm so grateful.
- 17:11SPEAKER_02: My skin looks better and everything feels more hydrated.
- 17:14SPEAKER_02: You know, uh, my skin appears more firmer and brighter.
- 17:18SPEAKER_02: So my skin tone and skin elasticity have improved dramatically.
- 17:21SPEAKER_02: So those comments are incredible.
- 17:23SPEAKER_02: And to be perfectly honest, we did not know that because the dolphins couldn't tell us that they were feeling better, that they were taking the skin.
- 17:34SPEAKER_02: So this has been a real delight and surprise.
- 17:37SPEAKER_01: That is so amazing.
- 17:39SPEAKER_01: I love that.
- 17:40SPEAKER_01: I I love that.
- 17:41SPEAKER_01: I love when consumers chime in.
- 17:42SPEAKER_01: That's such a promising, you know.
- 17:44SPEAKER_01: I think those are the most promising um like you know, bits of data and feedback that you could have, you know what I mean, as both scientists and also, of course, brand founders.
- 17:53SPEAKER_01: I mean, that's so phenomenal.
- 17:54SPEAKER_01: And you know, rightfully, it's it's very well deserved, and rightfully so because it I definitely see it myself.
- 18:00SPEAKER_01: You know, that's that's why I started the episode off the way I did, because I kid you not.
- 18:04SPEAKER_01: I mean, I think supplements for me, I'm not gonna lie, you know, I don't know if all of you out there are similar to me or not, but you know, I'm gonna just share my little story with you guys, um, if you don't mind.
- 18:16SPEAKER_01: And and that is that I've been very skeptical about supplements my whole life.
- 18:20SPEAKER_01: You know, I like as a kid, I've always suffered from things like depression.
- 18:24SPEAKER_01: Um, I always had really low like vitamin D levels for some reason.
- 18:28SPEAKER_01: I think it's like it was always hereditary for me.
- 18:31SPEAKER_01: So there were always things that were popping up in my like health overall that were just not, you know, they were just not things that you want to live with, right?
- 18:40SPEAKER_01: There were always problems.
- 18:41SPEAKER_01: And so I eventually ended up developing hypothyroidism.
- 18:44SPEAKER_01: And you know how it is, you know, uh Stephanie and Eric, you you guys know like when you develop something, your doctor's immediately gonna be like, Well, you need to get on this, this, this, and this.
- 18:52SPEAKER_01: You know what I mean?
- 18:53SPEAKER_01: Immediately.
- 18:54SPEAKER_01: So it's like that's where I was, you know, with my health.
- 18:57SPEAKER_01: And I um that's when I really started to turn to supplements.
- 19:00SPEAKER_01: And even then, it would take me so long to even incorporate one or two into my routine.
- 19:06SPEAKER_01: You know what I mean?
- 19:07SPEAKER_01: So, like, it's very rare if I stick to something.
- 19:10SPEAKER_01: And I've really stuck to Fatty 15 so far, you know.
- 19:14SPEAKER_01: Like I like I said, it's been almost, you know, two months since I've been using it.
- 19:19SPEAKER_01: I've really liked it.
- 19:20SPEAKER_01: It's easy to incorporate because it's not one of those giant pills that you have to take every day.
- 19:25SPEAKER_01: It's something that you can easily take, you know, throughout your day, where whenever it is that you take it.
- 19:30SPEAKER_01: And I have noticed in my energy levels, I've noticed, you know, and it's probably also my skin has been looking better.
- 19:36SPEAKER_01: I don't know if this is the only reason, but I use a lot of skincare.
- 19:39SPEAKER_01: But I mean, I'm sure it's definitely helping.
- 19:42SPEAKER_01: It's just that, you know, it's it's not causing any problems, is my point.
- 19:46SPEAKER_01: And that's where I'm trying to go with this, is that with supplements, for me as a consumer, it was always this battle of like, okay, I'm using this, but I don't like the effects of it.
- 19:56SPEAKER_01: You know what I mean?
- 19:57SPEAKER_01: Or I don't like some, I know something's not right.
- 19:59SPEAKER_01: I don't feel as amazing as I should or as as balanced as I should.
- 20:04SPEAKER_01: And that was always my story with supplements.
- 20:06SPEAKER_01: So when I would go and like tell somebody that, they'd be like, actually, you're making it up in your head, you know, you you just don't like supplements.
- 20:12SPEAKER_01: But it's true.
- 20:12SPEAKER_01: I always had a problem with it, but I've never noticed I didn't notice anything anything like that with Fatty 15, you know, and I only take um two other things.
- 20:20SPEAKER_01: One of them is a vitamin D daily vitamin D, and you know, the other one is just for my overall energy, like a vitamin B supplement.
- 20:27SPEAKER_01: So I don't I don't, you know, doubt anyone who leaves up a really raving review because I've definitely noticed that it's it's benefiting me, you know, in terms of energy.
- 20:38SPEAKER_01: It's definitely doing what it's supposed to do for me personally.
- 20:41SPEAKER_01: And I think that's something I really want to talk about is this idea of this cellular level of change that you guys had mentioned, you know, because as all of us know, you know, skill the skin is also composed of cells.
- 20:53SPEAKER_01: So I mean, I would love for you guys to talk about that, Stephanie or Eric, whichever person wants to take this on, is this idea of what it does for our skin cells, you know, what can the C15, you know, molecule really do for our skin cells?
- 21:08SPEAKER_00: Yeah.
- 21:09SPEAKER_00: So we're looking at each other, and I just um so yeah, so with the for the for the skin specifically, um it's it has several reasons of why it helps us.
- 21:23SPEAKER_00: Me personally, I I have uh lifelong um issues, it's had lifelong issues with um with atopic dermatitis of uh food-based allergies that then manifest itself, like eczema and you know, angry skin and dry skin and all these things.
- 21:40SPEAKER_00: So um it wonderfully for Fatty 15, it it's helped me um in many ways, but including that's where I personally saw the skin related benefits.
- 21:50SPEAKER_00: And so where the science um most strongly supports the benefits that we are getting from you know, from our customers, and I'm experiencing myself, um are.
- 22:00SPEAKER_00: Are twofold at least.
- 22:01SPEAKER_00: So the first is um it's incredibly good at decreasing multiple pro-inflammatory cytokines.
- 22:09SPEAKER_00: So as you know, inflammation drives a lot of issues, um especially related to the skin.
- 22:17SPEAKER_00: And so um it is likely that it has helped me for tamping this, you know, the the inflammatory responses um in my body, but including my skin.
- 22:30SPEAKER_00: The other, um, and it's dose-dependent, um, which is it's very compelling as far as that mechanism.
- 22:37SPEAKER_00: The other um is that you know, our cells, like we're talking about, are and including our skin cells, have lipids in them.
- 22:45SPEAKER_00: And it's the quality of the lipids in those skin cells that help dictate as far as you know how moisturized and plump right our skin feels.
- 22:55SPEAKER_00: And this is a lipid.
- 22:57SPEAKER_00: And so it is a fat that makes its way, we know it makes our its way to our skin cells, um, and that it, because of its role as a sturdy saturated fat, likely plays this role as just really being a healthy lipid that steps up to the plate, especially with regard to age-related changes um in our skin.
- 23:18SPEAKER_00: But to be honest, Ecta, you're probably your better point is to explain, you know, the specifics behind it, but those basic properties um absolutely explain, you know, how uh our customers are feeling what they're feeling, which we're thrilled.
- 23:36SPEAKER_00: You know, the intent wasn't for skin.
- 23:38SPEAKER_00: Um, but man, what a nice delight and surprise.
- 23:42SPEAKER_02: We get a lot of um, my skin is glowing testimonials, which is which is fun, which is fun.
- 23:47SPEAKER_02: I notice, you know, my skin is less dry, but I really noticed it my hair gets uh thicker.
- 23:52SPEAKER_02: In fact, we were looking into the studies behind that, and we actually found one study where they provided C15, I think it was topically, right?
- 24:00SPEAKER_02: And so to hair uh or to the scalp, and they found that the hair follicle, the ATP in the hair follicle uh levels went up like 350%, and they got a lot of uh hair growth.
- 24:13SPEAKER_02: We're not saying this is a hair growth product, and that was one study, but it's been interesting.
- 24:17SPEAKER_02: We get we get people saying, Hey, my barber's wondering why I have all these new this new hair growth and what to do.
- 24:24SPEAKER_02: So that's neat as well.
- 24:26SPEAKER_02: Yeah.
- 24:27SPEAKER_01: No, that's amazing.
- 24:28SPEAKER_01: And I think, you know, uh Stephanie, just to just to add to what you said, I I think it's so important to really hone in on these anti-inflammatory effects that you mentioned, because you know, a lot of times people have actually kind of you know slapped me on the wrist in previous years because I was so honed in on you know molecular biology here on this podcast about you know skin health.
- 24:48SPEAKER_01: And I would always be like shocked because I'm sitting here thinking, I'm like, well, if you don't care about the molecules, what the heck do you care about?
- 24:55SPEAKER_01: You know, so I think when we're talking about aging and we're talking about inflammation, you know, the this idea of really downregulating these pro-inflammatory cytokines, pro-inflammatory molecules, you know, this is really right now the cutting edge of skin health science.
- 25:13SPEAKER_01: You know, it's really, really out there at the forefront.
- 25:16SPEAKER_01: And so I can definitely see why people are saying things like, you know, this is helping my skin.
- 25:21SPEAKER_01: It's my skin is glowing.
- 25:22SPEAKER_01: Because, you know, at the end of the day, when people are having these flare-ups, right?
- 25:26SPEAKER_01: Of like eczema, for example, or they're having flare-ups of any kind of inflammatory process on your skin, that's an imbalance of doseytokines in your skin.
- 25:36SPEAKER_01: So when you're able to mediate that in any way, you know, sometimes we do it through things like, for example, marula oil, which is again, you know what I mean, an oil.
- 25:44SPEAKER_01: So again, we're dealing with fats and we're dealing with lipids, you know.
- 25:48SPEAKER_01: So if lipids have the ability to down-regulate that inflammation, that's probably a huge reason why you're seeing those effects.
- 25:57SPEAKER_01: I mean, that makes total sense to me.
- 25:59SPEAKER_01: Also, not to mention like moisturization.
- 26:01SPEAKER_01: You know, I think people have this misconception that moisture means that you load a bunch of, you know, humectants onto your skin.
- 26:08SPEAKER_01: But in reality, it's what I think both of you spoke about here, which is this composition of the lipid membranes that every single cell in our body has.
- 26:17SPEAKER_01: You know, the more lipids you put into our membranes, the less leaky they are, the less likely they are to break down or degrade.
- 26:25SPEAKER_01: And so when you're able to keep that moisture and that water content locked into cells, I mean, that's huge.
- 26:32SPEAKER_01: That means that your cells are gonna stay plump, they're gonna stay quote unquote hydrated, um, which they should be, you know.
- 26:39SPEAKER_01: And so that's gonna lead to better skin health overall.
- 26:42SPEAKER_01: So I can definitely see the logic of, you know, just on a molecular level, it's working on a molecular level to create this overall homeostasis for your skin that may get disrupted, you know, because of so many factors.
- 26:54SPEAKER_01: Like, you know, we have micro traumas throughout our day, UV radiation, pollution, you know, the the whole ecosystem that we live in.
- 27:02SPEAKER_01: I mean, just look at what happened in New York recently, you know, with the Canada fires and the smoke coming down and all that stuff.
- 27:08SPEAKER_01: So, you know, you we as consumers, we sit here and we don't really think about these things, but the long-term effects of being exposed to stressors like this is really dehydration, you know, and it's really damage to cellular membranes.
- 27:23SPEAKER_01: So I think to me, I'm not gonna lie, to me as a scientist, it makes complete sense.
- 27:28SPEAKER_01: It the science totally adds up.
- 27:30SPEAKER_01: You know, I'm sure the papers are um much more eloquent in the way they explain the data and all that, and I and I love that, but I I really think for the general consumer to be able to understand that and to see it from that perspective, like you guys you know, that's probably why it's working.
- 27:44SPEAKER_01: That's my opinion.
- 27:46SPEAKER_00: Oh, that's great.
- 27:46SPEAKER_00: I think you said it much better than we did.
- 27:48SPEAKER_01: So I oh no, I'm just I'm just reiterating what you guys were saying.
- 27:52SPEAKER_01: But you know, I really believe in this.
- 27:53SPEAKER_01: This is really, really cool stuff.
- 27:55SPEAKER_01: And I think one of my big questions, um, you know, Stephanie and Eric, both for both of you, is this idea of reverse aging, right?
- 28:02SPEAKER_01: Because um, we're hearing a lot about it.
- 28:04SPEAKER_01: We're hearing a lot about things like longevity science that's coming up, you know, through the woodworks.
- 28:09SPEAKER_01: There's a lot of longevity scientists out there that are talking about age, you know, reverse aging in a way where they're you're not becoming younger, but you're just taking that molecular stress off of your self, you know, the epigenetic level stress off.
- 28:23SPEAKER_01: And so I really want to talk to you guys about reverse aging and what, you know, how that fits into the context of Fatty 15 here.
- 28:30SPEAKER_00: Yeah, absolutely.
- 28:32SPEAKER_00: So, you know, so our cells, like we know, we get this all story always comes down for us at least to the cells, that what's nice is, you know, like you're saying, Ecta, that the science has really been evolving in aging and longevity field, in which, you know, there have been these defined hallmarks of aging, which all happen at the cellular level, which define how we break down with age, which is fascinating, right?
- 28:56SPEAKER_00: Because it anti-aging used to just be about skin.
- 29:00SPEAKER_00: When you said, you know, when you say anti-aging, we think, ooh, skin cream.
- 29:04SPEAKER_00: But now it's like it's it is evolving and expanding.
- 29:08SPEAKER_00: So now that it's understood specifically what happens in our cells that makes them age and therefore makes us break down with age.
- 29:17SPEAKER_00: If you can find molecules and compounds that can reverse those hallmarks of aging, then, you know, in theory, then you are reversing the aging process, which what's been fun is that this science is now advancing so much and so quickly that it's no longer theory, it's the now getting demonstrated um, you know, in relevant models.
- 29:41SPEAKER_00: It's uh it happen we're seeing in people.
- 29:43SPEAKER_00: So with C15 specifically, there are now 12 um hallmarks of aging.
- 29:50SPEAKER_00: Uh, we don't have six-hour uh podcast.
- 29:55SPEAKER_00: But the same um mechanisms we talked about of how C15 helps um with cell health, those are actually all hallmarks of aging.
- 30:02SPEAKER_00: So cellular stability, um, also called cellular senescence of like early loss of cells that become these zombie cells that don't get cleared.
- 30:10SPEAKER_00: Um, C15 activates this AMP K pathway that, well, first, C15 helps strengthen our cells so they don't become zombie cells in the first place.
- 30:20SPEAKER_00: But then, second, is that when our cells do die naturally, um, it's uh C15 activates this process called AMP K and inhibits MPOR.
- 30:29SPEAKER_00: That's as fancy as we're gonna get, um, to basically help clear out those zombie cells.
- 30:35SPEAKER_00: And that's a huge driver of, you know, helps uh basically mitigate a huge driver of aging, decreasing inflammation, also known as inflammaging, right, is a huge component of aging and then the mitochondrial function.
- 30:48SPEAKER_00: So all these things we've talked about are not just important, you know, for immediate needs for our skin and for health, but for the process of aging itself.
- 30:57SPEAKER_00: So that's kind of, and then what's been fun is um, you know, as we've less fun, what's been important is that large-scale epidemiological studies have shown just like we saw in the dolphins, people with higher C15 levels are less likely to have and develop type 2 diabetes, heart disease.
- 31:17SPEAKER_00: There's a whole series of fascinating papers of cancer, less likely to get cancer.
- 31:22SPEAKER_00: And the hypothesis now is that nutritional C15 deficiencies, which are being caused because we're in eating less C15 than we used to, um, may actually be driving the onset of these chronic diseases and in fact accelerating aging rates.
- 31:39SPEAKER_00: So the urgency of our movement has just gone up, you know, tenfold because it's not like we discovered something in tree bark, you know, that could that we never would have been exposed to.
- 31:51SPEAKER_00: It's like this is an essential nutrient we all need.
- 31:54SPEAKER_00: And if we don't have enough of it, then not only does it not protect us against aging, better aging may in fact accelerate.
- 32:03SPEAKER_01: Wow.
- 32:04SPEAKER_01: Yeah, that's really I, you know, I find it to be so fascinating because um uh you you mentioned a very important thing there, which is this idea of senescent cells, right?
- 32:13SPEAKER_01: I mean, I think that senescent cells, there's so much literature right now that's coming out on them, you know, overall.
- 32:20SPEAKER_01: But I think that this idea of really cleaning up these zombie cells, right, which is what we call them, um, is something that really I you don't hear about a lot, even in like the really deep science circles.
- 32:32SPEAKER_01: You know, you don't really hear a lot about it.
- 32:33SPEAKER_01: And I think, you know, it makes sense what you're saying because like, you know, for example, we talk a lot about things like, you know, natural cell death.
- 32:42SPEAKER_01: Like for everyone listening out there, I'm not gonna dive too heavily into the science, but like, you know, you hear a lot about, and scientists speak a lot about things like apoptosis, they speak a lot about your natural machinery that mops up, you know, dead debris or things that should be dead and gone, right?
- 32:58SPEAKER_01: But like for some reason, senescent cells are not immune to, but they kind of dodge that.
- 33:03SPEAKER_01: They're able to dodge these pathways and they're able to dodge these mechanisms.
- 33:08SPEAKER_01: And so if there's something that's able to help get rid of, you know, things that are just sitting around and causing other healthy cells to become unhealthy, I mean, that's huge.
- 33:18SPEAKER_01: That is a really huge breakthrough.
- 33:20SPEAKER_01: And I'm really curious to see, you know, in the coming years how this you know plays out because, you know, there's a lot of literature out there.
- 33:28SPEAKER_01: Some people are saying that it's it's you know, they're there for a reason.
- 33:32SPEAKER_01: Some people are saying no, they're just completely bad, you know, get rid of them kind of thing.
- 33:36SPEAKER_01: So I'm really curious to see what the papers say, you know, two, three years down the road.
- 33:39SPEAKER_01: But I mean, I know, for example, like when it comes to cell pro proliferation, sorry, you can't say that.
- 33:46SPEAKER_01: Um, and uh just health overall, you know, um, I don't know if you had mentioned the mTOR pathway or not, but um, I know C16 was involved in the MTOR pathway last I checked.
- 33:57SPEAKER_01: So I'd be curious to see if C15 is also um, you know, a key player there as well, because that's involved in like healthier cells, you know what I mean, in terms of like really helping them stay healthy.
- 34:08SPEAKER_01: And so um it's interesting, you know, the science, the molecular science is really interesting.
- 34:13SPEAKER_01: And I think um the more we we're gonna know the more we take it.
- 34:18SPEAKER_01: And that's the thing, that's where I really want to go with this conversation is this idea of like, you know, people are always looking for the next best thing when it comes to beauty, right?
- 34:27SPEAKER_01: And we're always looking for what can we do so that we don't have to pile on the products?
- 34:32SPEAKER_01: What can we do so that we don't have to keep spending dollars on these like ridiculous topical products?
- 34:38SPEAKER_01: And that's where, you know, I want to ask you guys, you know, what is your opinion about this idea of internal versus external beauty?
- 34:45SPEAKER_01: You know, what should we be focusing on as consumers?
- 34:49SPEAKER_02: Yeah, I think they're they're both important.
- 34:52SPEAKER_02: If I had to choose one, it would be, you know, internal health, right?
- 34:56SPEAKER_02: As you mentioned, as we've talked about, cells make up our entire body, all our organs, including our skin.
- 35:02SPEAKER_02: And so I, you know, this term is so overused, but health from the inside out is important.
- 35:09SPEAKER_02: Uh, you know, and it is certainly more and more important as we age, you know, as our cells begin to break down and as we start to get, you know, normal aging process, the uh you know, health from the inside becomes even more uh important.
- 35:24SPEAKER_01: Right, right.
- 35:25SPEAKER_01: I agree.
- 35:26SPEAKER_01: I think that's very important.
- 35:28SPEAKER_01: Stephanie, do you have anything to add to that?
- 35:31SPEAKER_00: Yeah, I I think um I know consumers are getting smarter and smarter, thanks to um folks like you, Ecta, who are keeping us all educated.
- 35:41SPEAKER_00: Um uh and so, and which I think is wonderful, right?
- 35:45SPEAKER_00: And and having consumers ask more and more questions and really starting to dive into the science, that I think what's wonderful is that this consumers are getting educated, their understanding that it's like, what makes more sense?
- 36:01SPEAKER_00: Like it makes sense to educate it to be able to take care of myself um for my cells inside.
- 36:08SPEAKER_00: Um, and by doing so, knowing that like Eric was saying, skin is a reflection of our whole body health, right?
- 36:15SPEAKER_00: Uh often.
- 36:16SPEAKER_00: And so we don't want to just fix just the skin.
- 36:20SPEAKER_00: We want to fix all of it.
- 36:21SPEAKER_00: We want to feel better.
- 36:22SPEAKER_00: We want and so if we we pair all of our cells um and including the skin, then that works, you know, that that's it's a win-win-win-win.
- 36:34SPEAKER_00: I don't know how many to we have like what how many trillion cells I'd have to say win a lot, but a lot of wins.
- 36:41SPEAKER_01: Exactly.
- 36:42SPEAKER_01: Yeah, no, I agree.
- 36:43SPEAKER_01: I I absolutely agree.
- 36:45SPEAKER_01: And I think, you know, we're all working, you know, at the at this common goal of just helping educate more as much as we can, right?
- 36:51SPEAKER_01: I mean, that's that's the goal is knowledge is, you know, it's the key to everything.
- 36:56SPEAKER_01: But I I really believe in this idea that we have evolved as you know, consumers.
- 37:01SPEAKER_01: Because I mean, do you guys remember when back in the day people were just like, oh yeah, I take my vitamins?
- 37:06SPEAKER_01: You know, like that was the statement everybody gave.
- 37:09SPEAKER_01: Like, oh yeah, I take my vitamins.
- 37:10SPEAKER_01: And they were really saying, I take my multivitamin every day.
- 37:13SPEAKER_01: But now it's like you talk to a consumer and you're like, well, what do you take?
- 37:17SPEAKER_01: What vitamins do you take?
- 37:18SPEAKER_01: And they'll know, they'll tell you, like, well, I take vitamin C, you know, so I don't get sick from the flu.
- 37:23SPEAKER_01: Or they'll say something like, Well, I take vitamin D for my bone health.
- 37:26SPEAKER_01: And now it's like, it's a whole different kind of, you know, understanding that we've come to, I feel like, as consumers and and people overall.
- 37:34SPEAKER_01: And I love that.
- 37:35SPEAKER_01: I love seeing that.
- 37:36SPEAKER_01: And that's where I feel like with um a product like Fatty 15, I love to see that there's this, you know, um almost like a cult following of real consumers that want to know the science because people are sick and tired.
- 37:50SPEAKER_01: I, and and this is my opinion and just my observation, they're sick and tired of taking things that they don't understand, you know, that don't logically make sense to them.
- 37:58SPEAKER_01: They want to know why.
- 37:59SPEAKER_01: And I love that knowing that, I love seeing that, you know.
- 38:03SPEAKER_01: You you guys would be shocked, you know, Eric and Stephanie.
- 38:06SPEAKER_01: You like people reach out to me every day and they're asking so many questions.
- 38:09SPEAKER_01: Like, even after all the knowledge that we gain here from such wonderful guests such as yourselves, you know, coming onto the show and educating us, we still get questions about, you know, well, tell us more, tell us more.
- 38:20SPEAKER_01: Like, how does this work?
- 38:21SPEAKER_01: And how why does this work for my rosacea?
- 38:24SPEAKER_01: Or can this work for my eczema?
- 38:26SPEAKER_01: What that shows me is the general consumer is now demanding answers.
- 38:31SPEAKER_01: And they, and you know, with with a product like fatty 15, this is a fatty acid that, you know, fatty acids uh you know, that are important in overall health.
- 38:40SPEAKER_01: You know, skin health is very important, but what about gut health?
- 38:43SPEAKER_01: What about heart health?
- 38:45SPEAKER_01: What about this idea of the gut-skin axis that we all keep talking about lately, you know, or the microbiome that we keep talking about lately?
- 38:53SPEAKER_01: What do you think fuels all of that, you guys?
- 38:55SPEAKER_01: It's good health overall for your cells, you know?
- 38:59SPEAKER_01: And so that's where I get so excited because you guys are here, you know, with a product that could really benefit, you know, really benefit a lot from the inside out on so many levels of overall skin health.
- 39:12SPEAKER_01: It's not just about, you know, hey, here's an enzyme that is going to eat away your dead skin cells on the surface, or here's it's not just it's overall health.
- 39:20SPEAKER_01: And so I completely agree with you what you said, which is, you know, there's trillions of cells and there's trillions of amazing things we could say.
- 39:26SPEAKER_01: But really, the idea, and I really want our listeners to walk away from this, knowing that if you invest in your body from the inside out, and this is my opinion, you know, and just to add to what Stephanie and Eric said, like if you really invest in your body, your skin's gonna show it, you know.
- 39:42SPEAKER_01: And I think, you know, Eric, you can agree as a physician, you know, we we see it all the time.
- 39:46SPEAKER_01: People who take care of themselves, like like exercise, you know, eat well, eat healthy.
- 39:52SPEAKER_01: I mean, everything, you know, it shows in every part of them, you know, their skin, their body, their heart, their gut, everything shows that.
- 39:59SPEAKER_01: So I really encourage you guys, you know, this is a winner, you know, in my book.
- 40:02SPEAKER_01: I love Fatty 15.
- 40:03SPEAKER_01: I, like I said, it's one of the three, you know, everyday supplements I'm taking right now.
- 40:09SPEAKER_01: I've been really, really loving it.
- 40:10SPEAKER_01: And I'm I'm just such a fan of the science.
- 40:12SPEAKER_01: Thank you so much for you know for coming on to the show and telling us about it.
- 40:16SPEAKER_01: I really, really uh love what you guys are doing.
- 40:19SPEAKER_02: Yeah, thank you.
- 40:20SPEAKER_02: Thank you.
- 40:20SPEAKER_02: I will uh I agree with what you're saying completely.
- 40:22SPEAKER_02: You know, my patients and our customers are very into the science, which is spectacular.
- 40:27SPEAKER_02: So much so that we created a newsletter, a weekly newsletter, just to see how people would respond, uh, where we go over what we're reading or the latest science on C15 or aging or something else.
- 40:39SPEAKER_02: And they have become, I mean, everyone opens those things.
- 40:42SPEAKER_02: And so it's outstanding.
- 40:44SPEAKER_02: It does mean we need to read more and write something every week, but uh and the people expect that.
- 40:51SPEAKER_02: And if you know, we we have it every Sunday, we miss just a few, and we get the where's where's our newsletter?
- 40:57SPEAKER_02: Where's my you know, science?
- 41:00SPEAKER_02: Science says so agreed, and you know, there is a this industry that's coming up of very high science, you know, molecules, supplements, nutrients, um, that that is because consumers are demanding it, like you're saying, and we're happy to be right in that space of you know, there's a lot of science supporting this, and it continues to grow, and we will continue to put that out there.
- 41:23SPEAKER_02: I mean, we haven't stopped, right?
- 41:24SPEAKER_02: And so we have some pretty incredible things uh coming up that we will be uh very interested with sharing with you soon.
- 41:32SPEAKER_02: One is in review at nature, so we can't talk about it yet coming soon.
- 41:35SPEAKER_01: Oh my gosh, that's so exciting! No, that's and by the way, I'm one of the people on your newsletter, and I love it.
- 41:42SPEAKER_01: So please keep them coming.
- 41:45SPEAKER_01: Do not stop the newsletters.
- 41:48SPEAKER_00: Well, I think this has been uh so much fun.
- 41:51SPEAKER_00: Um, thank you for having us having us with you.
- 41:55SPEAKER_00: It's been a fantastic.
- 41:56SPEAKER_01: Thank you.
- 41:56SPEAKER_01: No, thank you so much.
- 41:57SPEAKER_01: And I'm really excited, Eric.
- 41:58SPEAKER_01: You gave us a little teaser there, but I'm really excited to see what you guys come up with next.
- 42:03SPEAKER_01: And you know, for everyone listening, I really urge you guys, this is a real winner, you know, in my book.
- 42:08SPEAKER_01: And I really encourage everyone to try Fatty 15.
- 42:12SPEAKER_01: It's like I said, there I have not noticed any, like I don't even want to say side effect.
- 42:17SPEAKER_01: I haven't noticed anything negative at all.
- 42:19SPEAKER_01: It's just something I as part of my routine now, very easy.
- 42:22SPEAKER_01: Like I said, very, very easy to incorporate.
- 42:25SPEAKER_01: And, you know, I really, really want to hear back from you guys to see what you've noticed.
- 42:29SPEAKER_01: So please check them out.
- 42:30SPEAKER_01: I'm gonna tag everything in the concept art for this episode.
- 42:33SPEAKER_01: And um, if you have any questions at all, please feel free to reach out to us.
- 42:37SPEAKER_01: Um, anytime you can reach out to me directly or skincareanarchy at gmail.com.
- 42:42SPEAKER_01: Um, and we will pass all of your questions on to the Fatty15 team, get some answers for you.
- 42:47SPEAKER_01: Um, but I really, really want you to try this product because, like I said, you know, um, health is health, and you know, it's gonna reflect in your skin.
- 42:55SPEAKER_01: It really is.
- 42:56SPEAKER_01: So just check it out and let us know what you think.
- 42:58SPEAKER_01: And Eric and Stephanie, thank you guys so much.
- 43:01SPEAKER_01: It has been truly a delight to speak to you and learn from you.
- 43:05SPEAKER_02: Appreciate it.
- 43:06SPEAKER_02: Fun discussion.
- 43:07SPEAKER_02: Thank you.
- 43:08SPEAKER_01: Bye.
- 43:11SPEAKER_01: Hey guys, so I hope you love that episode.
- 43:13SPEAKER_01: Please make sure to hit subscribe if you're tuning in to us on any podcast platform.
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