Liver Cancer’s Hidden Engine: How Tumors Hijack Mitochondria to Survive, Spread, and Resist Therapy
Liver cancer (especially HCC) isn’t just uncontrolled growth, it’s mitochondrial adaptation. This Deep Dive breaks down how tumors repurpose mitochondrial defects (impaired OXPHOS, ROS imbalance, mtDNA damage, altered membrane potential, dysregulated mitophagy, calcium chaos) into a survival architecture that fuels proliferation, invasion, immune signaling, and drug resistance. We also map the therapeutic frontier: when to reduce oxidative injury (pre-malignant terrain) versus when to push tumor cells over the edge (pro-oxidant, ETC targeting, apoptosis re-sensitization), and why the future…
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