APOE4 Shrinks Brains Before Symptoms | Health and Fitness News

Health News Today | 2 Min News | The Daily News Now! · Aug 23, 2026 · 1m

Scientists have uncovered how the APOE4 gene, a top Alzheimer’s risk factor, sabotages brain health years before symptoms strike—by turbocharging a protein called Nell2 that shrinks neurons and overexcites memory circuits in young mice. This early hyperactivity predicts future cognitive decline, but here’s the kicker: lowering Nell2 in adult mice reversed damage, restoring normal neuron size and activity. This breakthrough identifies Nell2 as a promising new drug target, offering hope to halt Alzheimer’s progression in high-risk individuals long before it’s too late. Listen in comfort:Get a…