Prostate Cancer with PTEN Deficiency — An Interview with Dr Neeraj Agarwal

Oncology Today with Dr Neil Love · Oct 2, 2026 · 52m

Featuring an interview with Dr Neeraj Agarwal, including the following topics:

Impact of PTEN deficiency on PI3K/AKT/mTOR pathway; optimal approaches to testing (0:00)

Approaches to monitoring for disease progression in patients who are PTEN deficient; prognostic significance and implications for testing (7:13)

Potential usage of capivasertib as second-line therapy for metastatic androgen pathway modulation-naïve/-sensitive (APMN/S) prostate cancer (15:15)

Managing treatment-related adverse events from capivasertib (20:08)

Case: A man in his late 50s diagnosed with metastatic APMS prostate…