#261 ABG vs VBG Explained: Key Differences, Accuracy, and When to Use Each (Critical Care Guide)

WhiteBoard Medicine - Emergency And Critical Care · May 10, 2026 · 25m

Arterial blood gas (ABG) or venous blood gas (VBG)—which should you actually use in clinical practice? In this episode, we break down the key differences between ABG and VBG in a clear, practical way so you can understand when each test is appropriate in emergency and critical care settings. While ABGs are often considered the gold standard, VBGs can provide clinically useful information in many situations—with less risk and greater ease. We cover: What ABGs measure and how to interpret them What VBGs tell you and how they differ Key differences in pH, CO₂, lactate, and oxygenation The…