1571-Spatial Hi-C-RNA Maps 3D Genom&Transcriptome in Tissue
The paper introduce Spatial Hi-C-RNA, a pioneering multimodal platform designed to simultaneously map 3D genome architecture and gene expression within intact tissue sections. By integrating microfluidic barcoding with high-throughput chromatin capture and RNA sequencing, researchers can now observe how the spatial folding of DNA relates to transcriptional activity at near-single-cell resolution. The study demonstrates the technology's effectiveness across various biological systems, including the mouse brain, developing embryos, and human melanoma. Notably, the platform reveals intratumoral…
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