Mitochondria Don’t Just “Decline” With Age — They Lose Adaptability (And That May Be the Real Aging Engine)
In this Energy Code Deep Dive, Dr. Mike unpacks Mitochondria at the Heart of Aging: Structure, Function, and Failure — a sweeping review arguing that aging isn’t just random damage over time, but a progressive loss of mitochondrial adaptability. The episode walks through the core failure loops that accelerate aging across tissues: mtDNA instability → impaired oxidative phosphorylation → rising ROS → more mtDNA damage, plus breakdowns in fusion/fission architecture, mitophagy and quality control, NAD⁺ metabolism and sirtuin resilience, and the inflammatory spillover that turns mitochondrial…
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