201-C2S-Scale: Scaling Single-Cell Analysis with LLM

Paper Talk · Nov 1, 2025 · 14m

The paper present a preprint detailing C2S-Scale, a new family of Large Language Models (LLMs) designed for next-generation single-cell analysis. C2S-Scale is built upon the Cell2Sentence (C2S) framework, which converts high-dimensional single-cell RNA sequencing (scRNA-seq) data into textual "cell sentences" that can be processed by LLMs, enabling the integration of transcriptomic and textual biological data at unprecedented scales (up to 27 billion parameters). The authors demonstrate that scaling these models leads to consistent performance improvements across diverse tasks, including cell…