1412-IGFBP5+ Endothelial Drives Colorectal Cancer Metastasis
This research article examines how a specific protein, IGFBP5, secreted by endothelial cells, facilitates the spread of colorectal cancer to the liver. By analyzing single-cell RNA sequencing data, the authors identified that vascular invasion is driven by a specialized subpopulation of cells that remodel the tumor microenvironment. The study demonstrates that IGFBP5 binds to the ITGB3 receptor on cancer cells, triggering the PI3K/AKT signaling pathway to enhance tumor growth and mobility. Experimental results from organoids and animal models confirm that this molecular interaction weakens…
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