038-Senescence in cancer
This paper explores the multifaceted role of cellular senescence in cancer, defining it as a state of stable cell-cycle arrest that paradoxically acts as both a tumor-suppressive mechanism and a contributor to tumor progression. It details the hallmarks of senescent cells (SnCs), including their resistance to proliferation and apoptosis, and the complex senescence-associated secretory phenotype (SASP). The document further discusses various drivers of senescence in cancer, the consequences of SnCs within the tumor microenvironment (TME), and emerging therapeutic strategies that either induce…
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