1562-Cellular Landscapes of Cognitive Decline in ALS

Paper Talk · Sep 10, 2026 · 21m

This research utilizes multimodal spatial profiling to examine the biological factors behind cognitive decline in Amyotrophic Lateral Sclerosis (ALS). By integrating single-nucleus sequencing and spatial transcriptomics, the authors identified that different cognitive impairments arise from distinct cellular dysfunctions in the prefrontal cortex. Specifically, language deficits are linked to a broad, pan-regional response involving glial and vascular abnormalities. In contrast, executive dysfunction is associated with more localized changes in synaptic and mitochondrial activity within…