414-IGLL5+ B Cells Disrupt TLS Homeostasis and Response

Paper Talk · Jan 22, 2026 · 13m

Researchers have identified a specific IGLL5+ B cell subset that drives resistance to immunotherapy in bladder cancer by undermining the integrity of tertiary lymphoid structures (TLSs). These specialized B cells preferentially anchor to high endothelial venules (HEVs), where the IGLL5 protein acts as an inhibitory ligand for the LTβR receptor. This interaction triggers a conformational change that suppresses non-canonical NF-κB signaling, causing HEVs to dilate and lose their ability to recruit essential anti-tumor lymphocytes. Consequently, the destruction of the TLS microenvironment…