661-Pancreatic Cancer Organoid Biobank
This research details the creation of a massive pancreatic cancer organoid biobank used to investigate therapeutic resistance and personalized medicine. By performing comprehensive multi-omics profiling on 260 organoid lines, scientists identified novel genetic drivers in both coding and noncoding DNA regions that influence tumor growth. A key discovery revealed that chemoresistant tumors are characterized by elevated levels of protein glycosylation and cholesterol metabolism. The study demonstrates that statins can effectively reverse this resistance by blocking these metabolic pathways and…
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