1192-CytoSignal: Decoding Cellular Communication Dynamics
The paper introduces CytoSignal, a novel computational tool designed to map cell-cell communication using spatial transcriptomic data at single-cell resolution. Unlike previous methods that analyze broad cell groups, this approach identifies the precise locations and dynamics of signaling interactions for specific ligand-receptor pairs. The tool distinguishes between contact-dependent and diffusion-based signaling while also predicting how these interactions change over time through a framework called VeloCytoSignal. Researchers validated these findings using proximity ligation assays (PLA)…
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