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GLP-1s Gave Me the Ick: A Personal Metabolic Experiment
Ten pounds in two weeks. No hunger. No craving for coffee or alcohol. This is Jeff’s personal, week-by-week account of starting tirzepatide (sold as Zepbound), tracked through blood sugar, cholesterol markers, and a noticeable dimming of everyday motivation and joy.
What changed in the first two weeks: appetite, weight, and energy
Tracking glucose, LDL, ApoB, and other metabolic markers with a CGM and blood panels
Why alcohol and coffee stopped feeling rewarding
The emerging link between GLP-1s, dopamine, and the brain's reward circuitry
The trade-off between appetite control and a sense of…
The skinny
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