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When a Monthly Estrogen Shot Raised Men's Levels 17-Fold
When a Monthly Estrogen Shot Raised Men's Levels 17-Fold
A routine monthly injection sent one man’s estradiol to seventeen times his baseline within six months, while the men receiving it had been screened to have healthy hearts - a detail that should stop you cold. What was estradiol undecylate, how did a 100 mg oil ampoule produce sustained estradiol levels of nearly 600 pg/mL, and what unanswered risks lingered when the drug was retired?
In this episode, we tell the documented history of estradiol undecylate from its 1953 West German origins to multicenter trials in the 1980s, outlining…
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