Latest / Gladden Longevity Podcast / July Q&A - Episode 295
Transcript
- 0:28Welcome to the Gladden Longevity Podcast with Dr.
- 0:30Jeffrey Gladden, where our passion is helping you become an age hacker.
- 0:35On this show, we want to help you optimize your life energy, longevity, health and human performance with impactful and actionable information by answering four questions.
- 0:46How good can we be?
- 0:47How do we make 100 the new 30?
- 0:49How do we live well beyond 120?
- 0:50And how do we live young for a lifetime?
- 0:53I'm Steve Ryder back for another question and answer with you, Dr.
- 0:56Gladden.
- 0:57And it is July granted it's late July, but we do have some topics that we're going to be talking about.
- 1:02How's your July shaped up thus far?
- 1:04Great.
- 1:05Yeah, it's been great.
- 1:06It's been a good summer and it's good to see you again.
- 1:10I will just add this that we've added a fifth question, which is, yeah, how do we develop a 300 year old mine?
- 1:20that's awesome.
- 1:21Well, it is July and it is healthy vision and UV safety month.
- 1:27So how does UV related eye damage contribute to systemic inflammation and aging?
- 1:33Does it have a factor?
- 1:35Yeah, so that's an interesting question,
- 1:37I did a little research on this question.
- 1:39We've known that, interestingly enough, that it's early morning sunlight, right, before, let's call it 10 a.m., that actually triggers the brain to start making melatonin.
- 1:51It has a real impact on our circadian rhythm.
- 1:54And so getting early morning sunlight, like,
- 1:57first thing in the morning, if you can go outside and get grounded, get some early morning sunlight, it's doing a lot of really good things for you.
- 2:04However, if you're out in the bright sunshine, let's say between, depending on where you live, maybe it's 10 a.m.
- 2:11to 4 p.m., it's another story completely.
- 2:14And at this point, that really bright sunlight is causing a lot of inflammation, if you will, in the eyeball.
- 2:21Really?
- 2:21because it's a lot of energy coming in that's creating oxidative stress.
- 2:26And when you have oxidative stress, then you release a lot of inflammatory cytokines, right?
- 2:33IL-1, IL-6, TNF, alpha.
- 2:35And it turns out that those are activated not only in the eye, but they're put into the tears, they're reabsorbed into the body and they become systemic.
- 2:46So now when you're exposing your eyes to bright sunlight, you're actually not only increasing eye inflammation, which we can talk about some of the downsides of that, but
- 2:55you're also increasing systemic inflammation.
- 2:58And with that systemic inflammation, what they found is that it alters immune function.
- 3:04can drive ongoing low grade inflammation in the body, but also it can suppress,
- 3:10the immune system that makes it more difficult for it to work properly and, uh, impairs our ability to repair.
- 3:17So it's kind of a big deal.
- 3:18it can also increase advanced glycation end products, in the body and in the eye itself.
- 3:24you can almost think of, uh, bright sunlight, almost like causing many, central nervous system insults, right?
- 3:30So it can actually accelerate damage and neuroinflammation.
- 3:35Uh,
- 3:36in our brains.
- 3:37So it's kind of a big deal.
- 3:39Whereas early morning sunlight is really God's gift to you.
- 3:42Bright sunlight during the day can be a real problem.
- 3:45So pretty interesting.
- 3:47What kinds of nutritional and lifestyle strategies can support ocular longevity, especially in high UV environments like Colorado, where we are at least where I'm at.
- 4:00I'm at about 7,000 feet above sea level.
- 4:02Yeah.
- 4:03You have a double whammy and, it's sunny there pretty much all the time.
- 4:07I mean, you get the afternoon.
- 4:09300 plus days of sunshine a year.
- 4:11Right.
- 4:11And you do get in the mountains, you do get that afternoon thunderstorm frequently, which kind of mitigates it a little bit.
- 4:17But I think the number one thing is to get some sunglasses and you want to get these, you know, you've seen the guys, the mountaineers, right?
- 4:25With the kind of the wraparound sunglasses or the sunglasses that have the sort of the flaps on the side to keep extraneous light out.
- 4:33and those lenses are polarized for one thing, and they're also UV.
- 4:38400 certified, which means that they're basically block 100 % of the UVA and UVC light.
- 4:44And that cuts down the dose on your eye about 95 % apparently.
- 4:48So that's super important.
- 4:51I think the first thing is, if you're going to be out in the sun is to get some really good, expensive, high quality wrap around sunglasses.
- 5:01That's the first thing.
- 5:02And then, you know, when it comes to
- 5:05taking care of your eyes in general.
- 5:07It's interesting.
- 5:08You can do a genetics test that will look at genes associated with things like macular degeneration, right?
- 5:14Which it turns out all that bright sunlight can accelerate that.
- 5:18Some of the other things that Intellxx DNA, if I didn't mention that, is a company that has a really nice pivotal for that.
- 5:24That's uh I-N-T-E-L-L-X-X.
- 5:28The other thing that's
- 5:29Important to note is that smoking, if you have the genes for macular degeneration increases the risk of macular degeneration like 18 times.
- 5:40Yeah.
- 5:40So it's a big, it's a big, add and smoking in general, if you're going to be out in the sun is also adding, to the risk and primarily because it's using up a lot of your body's
- 5:51antioxidant capacity, right?
- 5:53alcohol is another problem.
- 5:56making sure you use blue filters on your phones, even if you're outside.
- 6:00And then there's certain supplements that you can take, right?
- 6:03So there's one called AREDS, which is kind of a composite capsule that we use for people with a risk of macular degeneration.
- 6:13And it contains some vitamin C, vitamin E, a little bit of beta carotene, which is a precursor to vitamin A, some zinc oxide, and a little bit of copper.
- 6:22uh And then if you combine that with N acetylcysteine, which of course makes glutathione.
- 6:27And if you drink molecular hydrogen, which helps you to block oxidative stress, you know, that becomes a pretty good strategy.
- 6:34Interestingly enough, they have also come up with some eye drops that have exosomes in them that can mitigate
- 6:45some of the, some of the issues, right?
- 6:48So that's pretty interesting.
- 6:50And now they're also have some platinum nanosyme eye drops that are apparently they're testing in primates that is showing some ability to decrease the reactive oxygen species.
- 7:01so yeah, pretty interesting.
- 7:03So anyway, the, the, the, the primary thing here is prevention.
- 7:07The first, you know, if we're just going to consolidate the thoughts here, the
- 7:12First line of defense is don't go out in the sun in the midday, right?
- 7:15Early in the morning, later in the afternoon, know, broad brimmed hats, anything that keeps you in the shade, excellent sunglasses, and then taking some of the supplements that
- 7:25we just mentioned becomes very important as well.
- 7:28So that's it.
- 7:29And of course, for your skin in general, we recommend the HelioCare, and there's now a HelioCare Ultra.
- 7:35which comes from polypodium leukotomus, which protects your skin when you're out in sunlight like that.
- 7:40So to your point, Steve, if you're in Colorado uh or Arizona or many places in the West that are sunny and dry and hot, depending on whatever, really becomes important.
- 7:52It's also important for people that are on the water, uh like fishing guides, right?
- 7:58yeah.
- 7:59fishing guides, either in rivers or lakes or in the ocean.
- 8:02Or even in the winter, you can think about it this way.
- 8:05If you're a snow skier or a snowmobile or a backpack or whatever you are, snowshoeing or whatever, you're getting cross-country skiing.
- 8:14Exactly right.
- 8:15You're going to get a ton of reflected light off that snow and that can be really, really intense.
- 8:21You know, people go quote unquote snow blind.
- 8:24So
- 8:25That's really important to keep in mind also.
- 8:27You really got to protect your, you know, what's coming into the eye, right?
- 8:31That's probably the most important.
- 8:33So, yeah.
- 8:35It's also Core Blood Awareness Month.
- 8:38We've talked a lot about stem cells over the course of the podcast.
- 8:43been waiting all year for Cord Blood Awareness Month.
- 8:48I know you have.
- 8:49So I guess first, before I ask my question, set it up for the listeners, the evolution of this little niche branch within the longevity field.
- 9:01Yeah.
- 9:01Well, basically it's, it's, conceptually, it's very simple.
- 9:06Younger biologic products have more regenerative capacity than older biologic products.
- 9:12Right.
- 9:13When you look at cord blood and there's also placental tissue, right.
- 9:17Which comes out at the same time cord blood does, we're talking about umbilical cord blood here.
- 9:22Just to be clear.
- 9:23and placental tissue, right?
- 9:25These are full of very, very youthful factors.
- 9:27The stem cells that are in here have long telomeres.
- 9:30There are many regenerative exosomes and forms of messenger RNA and other things that have incredible regenerative capacity, right?
- 9:40So if a baby, let's say in utero, suffers an injury, they can heal that injury and that you would never know it was injured.
- 9:47If a young child breaks their arm,
- 9:49right?
- 9:50The bone heals and it's like there was never a fracture there.
- 9:54So very youthful tissues like cord blood, like placental tissue, things like that can be incredibly regenerative.
- 10:02And so that's why people are really interested in this.
- 10:06So, yeah.
- 10:07How is this potentially going to be used in the aging reversal arena?
- 10:16it's used predominantly as an adjunct to other technologies, right?
- 10:21So what we've found is that in order to rejuvenate things in an older person, you first have to take out the old stuff, which kind of makes sense.
- 10:32The analogy I always use is that if you've got a youthful Olympic swimmer and you want them to go in and do, you know, amazing lap times in the pool,
- 10:41Well, you got to clean out the pool first, right?
- 10:43You got to take out all the logs, the twigs, the lawn chairs.
- 10:47You got to clear out the pool.
- 10:48Then you got to freshen the water, right?
- 10:50They can't swim in murky water and dirty water as efficiently, right?
- 10:56It's more friction, whatever else the analogy is.
- 10:58But the point is you've got to clear out the trash and you got to clean up the water.
- 11:02And then you allow them to go and then you've got to feed them.
- 11:05You've got to give them the right nutrients and you've got to give them enough NAD and you've got to give them the right peptides and things like this.
- 11:11Right.
- 11:11So when you actually get that right, when you get the sequence right, it's not just about a quote unquote stem cell or a cord blood product or a peptide for that matter.
- 11:21It's really how you clean up the environment.
- 11:24Then how you energize the rejuvenation therapies, how you link them together.
- 11:31And then how you actually support them going forward with more NAD peptides that actually are signaling molecules that keep the body kind of in a healing mode, hormone
- 11:41optimization, thyroid optimization, things like that.
- 11:44um Once you do this properly, you can get really remarkable results in an older individual who may have difficulty healing, healing a bone, healing a wound, things like that.
- 11:54So that's, that's the broad overview of it.
- 11:57We can get a little more specific if you like as well, but.
- 12:00Yeah, what kinds of early markers should be monitored to measure success in regenerative protocols using core blood derived interventions?
- 12:09Yeah.
- 12:10Well, a lot of, a lot of the problem with aging, of course, is that we end up with a lot of inflammatory markers.
- 12:15And these can be measured in the blood, uh, quite readily, quite readily, right?
- 12:20IL-6, IL-1, TGF alpha, TGF beta, things like this, can all be measured.
- 12:26And consequently, when you use products, like cord blood, et cetera, you can actually, see that there's a,
- 12:34a diminution of those inflammatory molecules.
- 12:37There are also ways to show that senescent cell burden is actually being decreased through a new test that we just got a hold of from a company SAPERE, SAPERE that can measure P16.
- 12:49P16 is a more specific measure of senescent cell burden than beta-galactosidase, which is better than nothing, but not as specific.
- 13:00And so...
- 13:01You can actually see impacts on P16.
- 13:04And then based on modifying the cytokinesis, inflammation and the associated oxidative stress, you can also look at measures of DNA methylation H and you can see that those
- 13:16improve as well.
- 13:17Right.
- 13:17So those are ways to kind of track and follow what's happening.
- 13:21So C-reactive protein can also be measured.
- 13:25And one of the things that seems to really
- 13:27augment the impact of cord blood is activating AMPK at the same time.
- 13:32So AMPK sits on one side of a teeter totter and mTOR sits on the other side, right?
- 13:38And they go up and down, but they're a teeter totter.
- 13:42you're low on one, you're high on the other and vice versa.
- 13:44And mTOR of course is building bone, building muscle, cell division, it's cell growth, et cetera.
- 13:50And it's a good thing until it's too much of it causes you to have cancer and you die sooner.
- 13:55Right.
- 13:55AMPK on the other hand, is what happens when we do fasting, when we do cardio exercise, when we take drugs like metformin or supplements like berberine, and it actually activates
- 14:06DNA repair and activates sirtuins and it requires NAD to also be present.
- 14:13so boosting NAD at the same time.
- 14:17becomes very, very important.
- 14:18And so we have ways to boost NAD with a couple of different products.
- 14:22Now, Vitality combined with Ducito Time, throwing some Apigenin as well, jump in an ozone sauna and you can really, really regenerate uh NAD concentrations.
- 14:33You really feel that.
- 14:34So anyway, again, it's about putting these pieces together in a way that makes sense.
- 14:39And then you can get some pretty cool results.
- 14:42You mentioned the ozone sauna, which you guys have one at the gladden longevity clinic, which I've done on the trip that I did out there last year.
- 14:49Would an Ibu treatment as well prior to the treatment with the cord blood stem cells help?
- 15:00Yeah.
- 15:00So we actually like to energize the system with NAD and many times we will use ozone in one form or another, whether it's ebu, which is filtering the blood and ozonating it,
- 15:11whether it's the ozone sauna to just, it's cheaper and faster to just jump on an ozone sauna for 20 minutes, or sometimes we'll inject ozone into a joint or an area, skin or
- 15:20wherever else to help energize the system.
- 15:23also, ozone itself decreases inflammation.
- 15:26seems to stimulate regeneration, decreases pain significantly, it works very good for pain.
- 15:31And then, you you combine these in the right sequence, right?
- 15:36So you wanna kind of get the bad stuff out, then start putting the good stuff in, then activating the good stuff with the ozone.
- 15:42So that's how we think.
- 15:44You said dialing up AMPK, things like fasting.
- 15:48Would a five day fast mimicking dial-
- 15:52We've had that.
- 15:52We've had that conversation on the podcast here with the prolon people.
- 15:56And I did one with them also at the longevity summit on the doctor talks uh network.
- 16:03Yeah.
- 16:04The prolon is great for activating AMPK, right?
- 16:07Because when you deprive yourself of calories or minimize calories,
- 16:11There's not enough calories around to activate mTOR.
- 16:14mTOR requires calories.
- 16:16It basically is monitoring amino acid levels.
- 16:19And then also uh insulin, which is part of the mTOR pathway.
- 16:23We think of insulin as just being glucose, but it's also part of the mTOR growth pathway is obviously monitoring glucose.
- 16:30So you're monitoring amino acids and glucose levels.
- 16:33And when those are replete, when you've got plenty of those, then you can activate mTOR.
- 16:37But when you fast and do a five day fast, and this is
- 16:41more powerful than just intermittent fasting.
- 16:43You can actually activate AMPK turn off mTOR.
- 16:47And then if you take spermidine on top of that, and spermidine is a wonderful molecule because it activates AMPK and autophagy and other things.
- 16:58Now you add spermidine into that.
- 17:00my gosh, you're really kind of like doing spring cleaning, like a very thorough spring cleaning.
- 17:05And so that's a great way to prep.
- 17:07We have many people prep for rejuvenation procedures, you know, doing a five day fast, mimicking diet, depending on who they are, what they're coming in with and that sort of
- 17:16thing.
- 17:16Yeah.
- 17:17Nice.
- 17:18It's also World Hepatitis Day on July 28th.
- 17:23I know you've been looking forward to this day.
- 17:25You said at the beginning, you've been looking forward to this.
- 17:29Well, it was Chord Blood I was really excited about, yeah.
- 17:33Day, how does chronic liver inflammation, viral hepatitis, accelerate aging at the cellular level?
- 17:41Yeah, so it's a question.
- 17:44know, chronic hepatitis, hepatitis C being a prime example.
- 17:54is really chronic inflammation in the liver and chronic inflammation in the liver increases oxidative stress, which increases damage, which increases the body's reaction to
- 18:03damage, which is ultimately fibrosis, which leads to cirrhosis, which leads to liver failure.
- 18:10Right.
- 18:10So there's a whole cascade.
- 18:12There's a reason why people don't live as long when they have chronic hepatitis.
- 18:16and it has to do with, a fast track to liver failure.
- 18:20But in addition to that, just having that inflamed liver basically sends out free circulating oxidized DNA, right?
- 18:28And that can lead to activation of the immune system systemically.
- 18:34And it's been found that the white blood cells in the immune system now have shorter telomere lengths than they would have otherwise.
- 18:40It's also activating systemic cytokines like IL-6 and TNF-alpha, right?
- 18:45And it turns out that when you activate those cytokines, you're now driving sarcopenia, which is a loss of muscle, right?
- 18:52And we know that the loss of muscle is not really about destroying the muscle cells.
- 18:57It's about destroying the neurons that innervate the muscles.
- 19:00That's why you lose muscle.
- 19:02And so that's really interesting.
- 19:04Yeah.
- 19:04And it also, now you're depleting your NAD pools.
- 19:08Right.
- 19:08So you have less energy to actually repair everything.
- 19:12and so when you put all this together, you end up with aging signals that get broadcast into the muscles, into the vasculature, into the immune system and also into the brain.
- 19:24Right.
- 19:24So it's a, it's a really big deal.
- 19:27There is no isolated organ in the body.
- 19:29You know, we just talked about how the eye,
- 19:31and exposure to bright light has a systemic impact.
- 19:34Well, if your liver's inflamed, you're aging yourself dramatically faster, right?
- 19:38And there are ways to follow liver function.
- 19:41An ultrasound can look for fatty liver, so can an MRI scan.
- 19:44There are also blood test routines that will look at probability of fatty liver, oh routine blood markers like ALT, AST, ALP, GGT, bilirubin, albumin, and...
- 19:56INR, has to do with clotting factors, along with C-reactive protein, all can give you insight.
- 20:02Measuring NAD levels can give you insight as to where you are.
- 20:06DNA methylation ages actually go up dramatically with chronic hepatitis, like eight to 10 years, right, with chronic hepatitis.
- 20:15So you're aging yourself systemically across the board.
- 20:18So it's pretty dramatic.
- 20:19Yeah.
- 20:21What sorts of regenerative tools can restore liver health?
- 20:25Yeah.
- 20:25So, you know, the biggest, driver of liver problems is non-alcoholic fatty liver disease, right?
- 20:33Um, the number of people that have chronic hepatitis is fairly small, but non-alcoholic fatty liver disease is predominantly related to either drinking too much alcohol or having
- 20:43insulin resistance.
- 20:44Right.
- 20:45So I know it's non-alcoholic, but when you're
- 20:48When you're drinking alcohol, you're actually changing the milieu and you become more sensitive to the other things.
- 20:53Now, if you drink a lot, you can damage the liver directly and cause problems, right?
- 20:57But non-alcoholic fatty liver disease sets the body up on this whole cascade of fat accumulation, inflammation, fibrosis, destruction, increased risk of liver uh cancer and
- 21:11death from liver failure.
- 21:13So, you know, when you talk about what can you do, well, some of the first things you can do is basically to control the lifestyle issues, right?
- 21:21So you don't want to be eating a lot of sugar.
- 21:24You want to monitor your insulin levels.
- 21:26You want to see what's happening there, right?
- 21:28You also want to look at liver function tests, et cetera.
- 21:31So you've got to start there.
- 21:33Then we've had good success actually.
- 21:37in non-alcoholic fatty liver disease by boosting AMPK.
- 21:40And we just talked about boosting AMPK with fast-memaking diets and then the drug metformin increases AMPK.
- 21:48So does berberine, resveratrol does, and then boosting NAD alongside that.
- 21:52And then milk thistle, right?
- 21:54Many people have heard of milk thistle.
- 21:56It turns out that it's very, very good at decreasing fibrosis markers in the liver.
- 22:02And then there's Tudka and...
- 22:03And UDCA, right?
- 22:05Tudka, T-U-D-C-A.
- 22:06Basically, these are metabolites of bile acids and they actually improve many things in the body.
- 22:13They're kind of antioxidants in a way, but they also improve liver function.
- 22:18And taking omega-3s can be good.
- 22:21And then when you want to get into the actual antivirals, right?
- 22:25There's a number of antivirals that have been, they're quite expensive.
- 22:28They're antibodies typically, but
- 22:31those can be used to actually treat the uh underlying issue.
- 22:35you can add to that some of the stem cell infusions, mesenchymal stem cells, anything that will quiet some of the cord blood things that we talked about, anything that will help to
- 22:44quiet down the inflammation can be useful.
- 22:48So, yeah.
- 22:50on a, it was actually a living beyond 120 podcast way back in your, in your podcasting journey, you guys were having success at reversing fatty liver disease.
- 23:04And, and, and I remember the guests at the time said within the regular doctor, traditional medical community, they thought it was irreversible.
- 23:16in general.
- 23:17we were told that, in fact, we had a guy that was on a transplant list.
- 23:21His father had died with cirrhosis and he'd been placed on a transplant list because of the status of his liver.
- 23:28we started him on a protocol.
- 23:30You know, that's, know more now than we did then, right?
- 23:33So that was maybe what, six or seven years ago?
- 23:35um And maybe, maybe, yeah, seven, at least seven years ago.
- 23:40And we focused primarily on activating AMPK.
- 23:43Uh, we didn't know about an NAD at that time.
- 23:46We didn't know how to really boost NAD.
- 23:48We didn't know about all the inflammatory cytokines that we could remove with plasma, freezes and all this kind of stuff.
- 23:53Right.
- 23:53We didn't know about monitoring his diet, um, cutting down on the carbs, things like that.
- 23:58So we did that.
- 23:59We had him stay away from alcohol and we just basically gave him, something called Stemia Silvestra.
- 24:05It's called immortality.
- 24:08it's a T actually.
- 24:10Doesn't taste great, but it's a T and it's a known potent AMPK activator.
- 24:14So we didn't even use yeah, Berberine or metformin.
- 24:17We used immortality and he went back to see his gastroenterologist about, I'm going to say three or four months later and they did a follow up echo in the office ultrasound because
- 24:28you can see fibrosis and fat on an ultrasound just in an office.
- 24:31You don't have to go for an MRI necessarily.
- 24:34And his liver had improved significantly and they took them off the transplant list.
- 24:38And the guy said, I have never seen this before.
- 24:40And I'm like, well, that's cool.
- 24:42We like that.
- 24:43So welcome to our world.
- 24:45Right.
- 24:46So yeah.
- 24:47I'm looking up immortality on, the internet and I'm seeing some ideas.
- 24:52I'm going to have to get me some of this because I do enjoy some tea, even though it doesn't taste good.
- 24:59If, if, if, if I would assume, I would assume if, if I'm doing a five day fast, mimicking diet or in that, you know, when I'm focused on the AMPK, I'm trying to rejuvenate my body,
- 25:11heal DNA, that kind of stuff.
- 25:13The adding that.
- 25:14to what everything else I'm doing would be a good thing.
- 25:17I would add that and some spermadine and, um, some of the NAD precursors would be a good thing also.
- 25:26And we've done a podcast previously on a product called Mimeo, which is basically, um, kind of a fast mimicking diet in a pill.
- 25:36Um, and guess what is in Mimeo?
- 25:39Spermadine, high amounts of spermadine, one with a little bit of niacin.
- 25:44And also some PEA and OEA.
- 25:45The PEA is good anti-inflammatory, particularly in the brain and the OEA curbs appetite.
- 25:51So when we're working with people, you uh know, getting them off their GLP-1s, the Memeo is one of the things that we go for.
- 25:58And also the five day fast memaking diet, because you can reset your appetite, your taste buds.
- 26:03It's not just your gut.
- 26:05It's not just that you have fewer calories.
- 26:07You're actually recalibrating your nervous system in terms of taste.
- 26:11desire for food, the gut biome, of course, if you've got the wrong bacteria down there, they're screaming for food.
- 26:17They're sending out signals, feed me, feed me, feed me.
- 26:20It's like, think of your intestine almost like a nest with baby birds in it, like feed me, feed me, feed me.
- 26:26So they're driving part of your appetite as well.
- 26:29And you can reset all of that with a five day fast-moving diet, which is pretty cool.
- 26:34Well, Mimeo is one of those supplements that I pretty regularly take and I'm low and I need to, I need to get it again.
- 26:41So thanks for that reminder.
- 26:44Now you and I over the last handful of months, you mentioned you guys are developing a course and an app.
- 26:54Let's, let's, let's tease that for the listeners.
- 26:58the book, 100 is the New 30, which involves four circles, life energy, longevity, health, and performance.
- 27:08And now we've added a fifth circle, which is the environments, focusing on the environments we reside in, right?
- 27:15Because we feel like true success is a function of making sure that each environment
- 27:21And we all live in four predominantly, right?
- 27:23Home, work, business, travel, vacation, architecting each of those four environments to support the mission.
- 27:29So that when you're, when you go to Italy, the wheels don't come off or when you take a week off and you go spend it with your family someplace, the wheels don't come off, right?
- 27:38It's like, how am going to exercise?
- 27:39Where's the food going to come from?
- 27:41You know, how easy can I make it for me to be able to take my supplements?
- 27:45You know, things like that.
- 27:46So intentionally architecting the, at that level.
- 27:49But then also what's the water quality?
- 27:51What's the air quality?
- 27:52Is there mold in the facility?
- 27:54You know, all these kinds of things.
- 27:56If you architect that for people, all of a sudden it's so much easier for them to make progress because they're being reinforced.
- 28:03Their progress is being reinforced in every environment they go into.
- 28:06Right.
- 28:06So that's a big deal.
- 28:07So that's kind of the fifth circle.
- 28:09So we created a course to train people on actually how to implement.
- 28:14The book is full of tremendous information, right?
- 28:18But I didn't, I wrote it in such a way that it wasn't, didn't end up being like terribly actionable in the sense of, okay, now I know what to do.
- 28:26It's like, now I understand what the problems are and I understand what the solutions could be, but I don't know exactly what to do for me based on the book, because it's hard
- 28:35to make a book that's specific to everybody.
- 28:36In the course, we're going to break it down so that people can actually see.
- 28:42You know, okay, what tests do I need to do?
- 28:45And then what do I need to do about those tests when I get them?
- 28:47Right?
- 28:48So this is a, this is a course that we're bringing forward to the, to the public.
- 28:52So we're excited about that.
- 28:53It's we've been working on it, refining it.
- 28:56Um, we were going to bring it forward initially just for practitioners.
- 29:00and then we realized, you know, this would probably have more benefit for more people if we brought it out to the general public.
- 29:06And of course practitioners will, will benefit from it too.
- 29:10So we're.
- 29:11we're reducing the cost significantly and trying to make it accessible for people.
- 29:18And we're still fine tuning it, but we should have it out fairly soon.
- 29:22So yeah, that's the idea behind the course.
- 29:24let's learn, but not only that, but let's learn what I need to do and make it actionable.
- 29:28So.
- 29:29Well, go to gladdenlongevity.com, sign up for the email list so that way you can be first to know when this comes out.
- 29:37And for many of those supplements that we talked about here on the podcast, they're available in the Gladden Longevity Shop.
- 29:44Just go to gladdenlongevityshop.com, enter promo code podcast10 and get 10 % off of your order.
- 29:52Dr.
- 29:53Gladden, anything else?
- 29:55Yeah, we're working on an app that I'll tell you about.
- 29:58Super excited about this.
- 30:00It's a multi-agent AI app, meaning there are multiple AI agents that are in the backdrop.
- 30:05We're going to be bringing it forward for beta testing in September.
- 30:08It's going to be coaching off the five circles.
- 30:10And we've trademarked a name that we like a lot.
- 30:13It's called the Longevity Wingman.
- 30:14And so...
- 30:15What the app is there to do is to kind of be your best friend, your best buddy, to help help you make everything as easy as possible.
- 30:22Right.
- 30:22Like I'm going to New York next weekend.
- 30:26Where should I stay?
- 30:28Where's a hotel that has the right workout room, the right sauna?
- 30:30Where are the restaurants I should have?
- 30:32Who's going to have the right food?
- 30:33All of that's done through for you through the app.
- 30:36I can order tests.
- 30:38I can keep track of my supplements.
- 30:40It'll keep scorecards for you around all the circles in terms of where am I?
- 30:44on the longevity, health, performance, and life energy circles.
- 30:48Here are resources for me to continue to build.
- 30:50It's going to be an ability to, on the app, order what you need, whether it's testing or supplements or equipment, so that everything is right in the palm of your hand.
- 31:01It's like, how easy can this be?
- 31:03How easy?
- 31:04The thing that's driving it for me is realizing that longevity
- 31:09not only is it a journey, but it takes time and attention.
- 31:12So how can we make it as easy as possible for people, right?
- 31:15They can upload their labs.
- 31:16We're actually creating connections now where if people click on the lab and order it, they can have it done at their home or they can go to a place close to them to have it
- 31:26done.
- 31:27We'll automatically scavenge the, or collect the data from that, put it back in the app.
- 31:32So ultimately we're going to know more about them.
- 31:35than anybody else and be able to coach them through this multi-agentic AI on things that are actually appropriate for them.
- 31:41So it's incredibly personalized and specific to the individual and it'll have all kinds of really cool features.
- 31:48anyway, be on the lookout for the longevity wingman.
- 31:50That's going to be very cool.
- 31:51count me among those that wants to beta test once you guys have that beta test version up there.
- 31:58Because I'd love to give my feedback on here as well once once it's actually live.
- 32:03Yeah, absolutely.
- 32:03No, we'll be sure to include you.
- 32:06Dr.
- 32:06Gladden, thanks so much for another Q &A, monthly Q &A.
- 32:12What are the big plans for August?
- 32:16Hmm.
- 32:16Big plans for August.
- 32:18you know, finishing the app right now.
- 32:19I'm really, really in the middle of that, finishing the app and a little bit of travel.
- 32:25so trying to stay out of the heat, get my mountain biking in early in the day here in Texas this summer.
- 32:31So all good, but it's all good.
- 32:34you come to Colorado, let's set up a 14 or a 13 or together and do another hike together.
- 32:41Yeah, we'll do it.
- 32:42I love it.
- 32:42Wear our sunglasses.
- 32:44All right.
- 32:46Later.
- 32:47Yeah.