1591-Functional Chimeric mRNAs in Mammalian Immunity
The paper describe the discovery and functional characterization of chimeric mRNAs (chRNAs), which are formed by fusing exons from distinct genes. Researchers utilized a sophisticated pipeline involving long-read RNA sequencing to identify thousands of these hybrid transcripts in mammalian macrophages during inflammation. A primary finding is the Gsdmd-Tmem106a chimera, a protein-coding fusion that is dynamically regulated by CTCF-dependent chromosomal interactions. This novel protein localizes to the plasma membrane, where it physically interacts with canonical GSDMD to accelerate the…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.