1343-A Quantitative Spatially Resolved Map of Human Proteome

Paper Talk · Jul 27, 2026 · 22m

This comprehensive study establishes a detailed quantitative map of the human proteome, profiling over 13,000 proteins across various physiological states and 58 major tissue types. By utilizing data-independent acquisition mass spectrometry, researchers analyzed samples from healthy adults, fetuses, and patients with 25 different types of cancer. The resulting dataset provides a spatial distribution of proteins that illuminates both natural human development and the progression of oncogenic diseases. The research identifies tissue-enriched drug targets to help predict organ-specific…