952-Deconstructing the Memory Engram

Paper Talk · May 12, 2026 · 21m

This research article investigates how specific groups of neurons in the dorsal CA1 region of the hippocampus form the physical basis of memories, known as engrams. By using a high-precision tool called f-FLiCRE, scientists tagged brain cells based on their activity during distinct moments of fear conditioning in mice, such as during the electric shock or subsequent freezing behavior. The study reveals that the memory engram is not a uniform set of cells but is instead composed of distinct subensembles that correspond to specific stimuli and internal states. Crucially, the authors found that…