1689-γδ T Cells Modulate Anti-Tumor Immunity
Recent research reveals that γδ T cells infiltrate small cell lung cancer (SCLC) tumors and lymph nodes, where they maintain functional cytotoxic profiles capable of mounting anti-tumor responses. Although conventional T cell pathways often fail in SCLC due to the downregulation of MHC-I, high levels of γδ T cells strongly predict improved clinical outcomes and prolonged overall survival when patients are treated with anti-PD-L1 immunotherapy. Furthermore, preclinical and patient-derived models demonstrate that these innate-like immune cells can be effectively redirected to destroy cancer…
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