489-MYRF: Regulator of Lung Mesothelium Fate and Plasticity

Paper Talk · Feb 9, 2026 · 14m

Luna et al. found that Myrf is essential for mesothelium function and lung development. Deleting Myrf causes lung hypoplasia and congenital diaphragmatic hernia (CDH). Without Myrf and Yap/Taz, mesothelial cells transform into ectopic smooth muscle, mimicking adult PPFE.

References:

Luna G, Verheyden J M, Tan C, et al. MYRF controls mesothelium specification, signaling, and plasticity in lung development[J]. Developmental Cell, 2026.

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