546-Male-Biased Yap1-CD276 Axis in Medulloblastoma
This research explores the sex-based differences in the development and treatment of medulloblastoma (MB), specifically focusing on the Sonic Hedgehog (SHH) molecular subtype. The study identifies Yes-associated protein 1 (Yap1) as a critical oncogene that functions differently in males and females, showing that its removal significantly increases survival rates in males. This improvement is driven by a heightened immune response, where the loss of Yap1 triggers the recruitment of CD8+ T cells to attack the tumor. In contrast, females exhibit more immunosuppressive environments that prevent…
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