212-Neuroimmune Circuit Enables Cancer Immune Evasion

Paper Talk · Nov 6, 2025 · 13m

This article investigates how cancer, specifically head and neck squamous cell carcinoma (HNSCC) and murine oral cancer models, utilizes a neuroimmune circuit involving distant organs to evade the immune system, thereby compromising the effectiveness of immune checkpoint blockade therapy. The research details a complex mechanism where cancer cells, under immune pressure, secrete a ligand (SLIT2) to activate nociceptive neurons, which subsequently remodel tumor-draining lymph nodes (TDLNs) into an immune-suppressed state. Through various advanced techniques like CyTOF, scRNA-seq, and…