1568-Synthetic Transcription Factors for CAR T Cells
This paper describe the development of DESynR, a high-throughput molecular platform designed to engineer synthetic transcription factors by recombining protein domains from natural gene families. By shuffling these structural building blocks, researchers created thousands of non-natural genes that were screened to enhance the therapeutic performance of CAR T cells. The study identifies specific synthetic variants, such as JUN-FOS-BATF, that significantly outperform natural proteins in promoting antitumor immunity, persistence, and cytotoxicity. These engineered factors work by reprogramming T…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.