AI Supercharges CRISPR & LIGO (Nobel Prize Week Preview) (EP. 10)

From First Principles · Oct 2, 2025 · 2h 36m · transcript

Hosted by Lester Nare and Krishna Choudhary, this two-story, 2.5-hour special sets the table for Nobel Prize Week with deep dives into two recent Nobel-winning domains—gene editing (CRISPR) and gravitational waves (LIGO)—and how AI is accelerating both. We trace CRISPR from bacterial immunity to Stanford’s new “CRISPR-GPT” lab co-pilot, then pivot to how machine learning upgrades are pushing LIGO past its noise limits to capture new classes of gravitational waves.

Summary

• CRISPR, from bacterial immune memory to RNA-programmable genome editing

• The 2012 Science breakthrough: guide RNAs…