PSYCH 041: Neuropsychiatric Aspects of Prion Disease
Prion diseases are among the most unsettling conditions in medicine - rare, rapidly progressive, and fundamentally destructive. This chapter explores how abnormal protein folding can lead to profound neuropsychiatric decline.
In this episode, we examine how prions - misfolded proteins - propagate by inducing normal proteins to adopt the same abnormal structure. This creates a self-amplifying cascade, leading to widespread neuronal damage.
Clinically, prion diseases often present with early psychiatric symptoms - anxiety, depression, behavioural change, or psychosis - before progressing to…
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