1144-scNiche: Decoding Multi-View Cell Niches

Paper Talk · Jun 17, 2026 · 20m

The paper introduces scNiche, an innovative computational framework designed to identify and characterize cell niches using single-cell resolution spatial omics data. By integrating multi-view features—including the molecular profiles of individual cells and their surrounding microenvironments—the tool successfully deciphers complex tissue structures and cellular interactions. The researchers validated scNiche across diverse biological contexts, such as mapping the tumor-immune interface in human breast cancer and tracking tissue remodeling during liver failure. Benchmarking results…