1339-Phage-Fibroblast-B Circuit in Stressed Tumor Growth
The research demonstrates how chronic stress accelerates cancer progression by activating a specific biological circuit involving the gut microbiome, fibroblasts, and immune cells. According to the study, persistent stress damages the intestinal barrier, allowing a specific gut bacterium, Enterococcus gallinarum, to escape the digestive tract and infiltrate tumors. Once inside the tumor microenvironment, phage DNA released by these bacteria triggers cancer-associated fibroblasts to produce local glucocorticoids. These steroid hormones directly suppress the activity of germinal center B cells…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.