1633-Lymph Node Tpex Reservoirs Boost ICI Immunity
This research study examines how immune checkpoint inhibitors (ICIs) enhance anti-tumor responses in gastrointestinal cancer patients. By employing advanced single-cell sequencing and a novel anti-IgG4 detection method, researchers tracked the behavior of progenitor-exhausted T cells (Tpex) across tumors, blood, and lymph nodes. The findings reveal that lymph nodes act as critical reservoirs where therapeutic antibodies bind to Tpex, triggering their proliferation and clonal expansion. These activated cells subsequently migrate to the tumor microenvironment, where they differentiate into…
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