1625-Viral Autonomy in Membrane Remodelling
The research paper describes the groundbreaking discovery of ESCRT-III and Vps4 ATPase homologues within the genomes of mirusviruses and some nucleocytoviruses. Traditionally, enveloped viruses were thought to only hijack host cell machinery to facilitate membrane remodeling and budding, but these sources demonstrate that certain large DNA viruses actually encode their own functional components. Phylogenetic analysis suggests that mirusviruses likely acquired these genes very early in their evolution, potentially dating back to the initial diversification of eukaryotes. Structurally, these…
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