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Illuminating the Dark Genome – New Insights into the Genetic Basis of Disease
The biorevolution podcast #34
More than 20 years after the Human Genome Project, enabled by new sequencing technologies, researchers are making progress in exploring the vast non-coding space that constitutes 98% of our genomes. This non-coding, or "dark," DNA harbors elements with important regulatory functions in health and disease. But pinpointing disease-relevant DNA elements within this massive DNA space can be like searching for a needle in a haystack. This difficult search can be eased by artificial intelligence (AI)-based tools, which predict the context-dependent relevance of certain…
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