826-Fibroblast NF-κB Activation Drives Lung Inflammaging

Paper Talk · Apr 20, 2026 · 22m

The article examines how fibroblast cells orchestrate inflammaging, the chronic pro-inflammatory state associated with aging. The study identifies that the activation of the NF-κB signaling pathway in these structural cells triggers a biological circuit involving macrophages and T cells, leading to the formation of organized immune aggregates in the lungs. This process promotes the emergence of specialized GZMK+ CD8+ T cells that exhibit unique characteristics of both exhaustion and active inflammation. These specific immune cells are shown to increase vulnerability to acute respiratory…