1316-Arc Packaging Mediates Intercellular Tau Transmission
The research explores how the neuronal protein Arc drives the spread of Alzheimer’s disease pathology by packaging toxic tau protein into extracellular vesicles (EVs). Through direct protein-protein interactions, Arc facilitates the release of seed-competent tau from neurons, enabling its transmission to healthy recipient cells. Findings in both mouse models and human postmortem brains demonstrate a strong correlation between Arc levels and the presence of phosphorylated tau within these vesicles. While this process may initially help donor neurons eliminate internal toxins, it ultimately…
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