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1618-Multimodal Immunofluorescence for Cancer Biomarkers

This report introduces Orion, a multimodal imaging platform that captures high-plex immunofluorescence and traditional H&E histology from a single tissue section. By combining molecular depth with classic anatomical insights, the system allows researchers to identify specific cell types and states that are often invisible when using either method alone. The authors validated the technology using colorectal cancer cohorts, demonstrating that the platform's spatially resolved data can be processed by machine learning algorithms to predict disease progression. This integrated approach achieves a…

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