1436-Hypothalamic GABAergic Circuits Drive Neuroprotection
This research article examines how a specific neural pathway in the hypothalamus can be manipulated to protect the brain from ischemic stroke damage. By utilizing chemogenetic and optogenetic techniques in mice, the researchers identified that inhibiting certain GABAergic neurons in the dorsomedial hypothalamus (DMH) or activating projections from the ventrolateral preoptic area (vlPOA) induces a state of therapeutic hypothermia. This internally regulated cooling significantly reduced infarct volume, decreased brain swelling, and improved overall neurological recovery by limiting reperfusion…
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