244-T-SenSERs: Design Synthetic Receptors for Enhanced CAR-T
The paper describes a study on developing synthetic receptors for enhancing CAR-T cell therapy against cancer. Researchers used a computational design platform to create allosteric switch receptors, named T-SenSERs, that respond to soluble factors in the tumor microenvironment (TME), specifically VEGFA or CSF1, with co-stimulation and cytokine signals. The goal is to overcome limitations of current CAR-T therapies, particularly in solid tumors, by providing context-dependent activation and boosting T cell persistence and anti-tumor function. Experimental validation in both lung cancer and…
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