1685-Glioma Metabolism Drives Neuronal Activity
Recent scientific findings reveal that high-grade gliomas accumulate massive amounts of the metabolic intermediate guanidinoacetate (GAA) due to imbalanced enzyme activities in the creatine synthesis pathway. Rather than producing creatine, tumor cells heavily secrete GAA into the surrounding brain tissue, mirroring conditions seen in inborn errors of metabolism like GAMT deficiency. Researchers discovered that this secreted GAA acts as an agonist for GABA A receptors, triggering depolarizing currents in peritumoral neurons that display dysregulated chloride homeostasis. Consequently, this…
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