Micro 37 – Mechanisms of Viral Pathogenesis
This episode explores how viral replication translates into tissue injury and clinical illness. Drawing from Murray’s Chapter 37, it examines the mechanisms through which viruses cause damage - directly and indirectly.
The narrative begins with cytopathic effects: viral replication disrupting cellular function, inducing apoptosis, forming syncytia, or triggering lytic destruction. Yet not all viral disease is due to direct cytotoxicity. Immunopathology plays a central role - host immune responses, particularly cytotoxic T lymphocytes and inflammatory mediators, may cause more damage than the…
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