Dr. Marcela Mazo Canola, Dr. Akshjot Puri, & Dr. Giancarlo Moscol - AKT-Pathway Sequencing in ER+ mBC

Community Health Media · Jun 25, 2026 · 29m

How do we navigate the increasingly complex second-line landscape for HR+/HER2- metastatic breast cancer?

Dr. Marcela Mazo Canola, Dr. Akshjot Puri, and Dr. Giancarlo Moscol discuss the art of sequencing therapies post-CDK4/6 progression and the evolving role of MRD and circulating tumor DNA (ctDNA) monitoring across ER+ mBC. They discuss the critical clinical judgment required when targeting the PI3K/AKT pathway and managing ESR1 mutations, including how to proactively mitigate toxicities and when to pivot strategies based on patient-specific factors.

Topics include:

Using ctDNA to guide…