933-Deep Drainage and White Matter Decline in Aging Brain
This research investigates how aging affects cerebral white matter by examining the microvascular networks in mice. Using advanced deep multi-photon imaging, researchers discovered principal cortical venules (PCVs), which serve as the primary drainage system for deep brain tissues and the corpus callosum. The study found that aging causes capillary rarefaction and constriction specifically within these drainage branches, leading to hypoperfusion. This restricted blood flow is directly linked to demyelination and inflammatory responses like gliosis. By simulating similar conditions in younger…
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