1199-Modeling Primate Embryogenesis from Totipotency

Paper Talk · Jun 28, 2026 · 20m

This article describes the creation of a comprehensive primate embryoid system derived from cynomolgus totipotent blastomere-like cells (cTBLCs). By using a specialized culture method to repress the spliceosome, researchers successfully reprogrammed pluripotent stem cells into a totipotent-like state that mimics the earliest stages of life. These cTBLCs can autonomously self-assemble into blastoids without the need for external signaling molecules, eventually progressing through gastrulation and into early organogenesis. The resulting structures exhibit complex features such as neural tubes…