1444-Breast Cancer Brain Metastasis progression
This research article examines the molecular and cellular dynamics of breast cancer brain metastasis using high-resolution single-cell and bulk DNA sequencing. The study identifies 63 distinct cell clusters, highlighting a significant shift in tumor-associated macrophages from inflammatory circulating phenotypes to immunosuppressive tissue-resident states. Analysis of metastatic tumor cells reveals a "neuro-related" subtype that adapts to the brain by hijacking neuronal signaling pathways and increasing cell adhesion. The authors identify GABRB3 and NRXN1 as critical mutated genes that are…
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