Week 2 2025 College Football Picks for the 10 Biggest Games!

Winning Cures Everything | College Football · Sep 2, 2025 · 45m

College football Week 2 is here, and we’re breaking down the 10 biggest games of 2025 with picks, odds, and analysis. From Michigan–Oklahoma in Norman to Ole Miss–Kentucky in Kroger Field, it’s a loaded slate with rivalry spice and upset alerts.We cover:

1:11 Michigan at Oklahoma – Wolverines’ front vs Sooners’ firepower, Bryce Underwood’s first true road test

4:34 USF at Florida – Golesh’s tempo vs Gators’ trench edge, look-ahead factor with LSU on deck?

7:52 Kansas at Missouri – Border War returns, Jalen Daniels vs Kirby Moore’s balanced Tigers

11:45 Iowa at Iowa State – Cy-Hawk trends…