752-Engineered Living Glues for Inflammatory Bowel Disease

Paper Talk · Apr 6, 2026 · 24m

This research describes the development of therapeutic living glues (TL-glues) designed to treat inflammatory bowel disease (IBD) using genetically modified E. coli. These bacteria feature a sophisticated blood-sensing module that triggers the secretion of barnacle-derived adhesive proteins and healing factors only when gastrointestinal bleeding is detected. By mimicking the natural adhesion of barnacles, the engineered microbes can firmly attach to inflamed intestinal walls for up to ten days, providing a localized and sustained medicinal effect. Experimental results in mouse models…